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Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework
Introduction: Despite much research, interventions to improve medication adherence report disappointing and inconsistent results. Tailored approaches that match interventions and patient determinants of non-adherence were seldom used in clinical trials. The presence of a multitude of theoretical fra...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107738/ https://www.ncbi.nlm.nih.gov/pubmed/27895583 http://dx.doi.org/10.3389/fphar.2016.00429 |
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author | Allemann, Samuel S. Nieuwlaat, Robby van den Bemt, Bart J. F. Hersberger, Kurt E. Arnet, Isabelle |
author_facet | Allemann, Samuel S. Nieuwlaat, Robby van den Bemt, Bart J. F. Hersberger, Kurt E. Arnet, Isabelle |
author_sort | Allemann, Samuel S. |
collection | PubMed |
description | Introduction: Despite much research, interventions to improve medication adherence report disappointing and inconsistent results. Tailored approaches that match interventions and patient determinants of non-adherence were seldom used in clinical trials. The presence of a multitude of theoretical frameworks and models to categorize interventions and patient determinants complicated the development of common categories shared by interventions and determinants. We retrieved potential interventions and patient determinants from published literature on medication adherence, matched them like locks and keys, and categorized them according to the Theoretical Domains Framework (TDF). Methods: We identified the most relevant literature reviews on interventions and determinants in a pragmatic literature search, extracted all interventions and determinants, grouped similar concepts to umbrella terms and assigned them to TDF categories. All steps were finalized in consensus discussion between the authors. Results: Sixteen articles (5 with determinants, 11 with interventions) were included for analysis. We extracted 103 interventions and 42 determinants that we divided in 26 modifiable and 16 unmodifiable determinants. All interventions and modifiable determinants were matched within 11 categories (Knowledge; Skills; Social/professional role and identity; Beliefs about capabilities; Beliefs about consequences; Intentions; Memory, Attention and decision processes; Environmental context and resources; Social influences; Emotion; and Behavioral regulation). Conclusion: In published trials on medication adherence, the congruence between interventions and determinants can be assessed with matching interventions to determinants. To be successful, interventions in medication adherence should target current modifiable determinants and be tailored to the unmodifiable determinants. Modifiable and unmodifiable determinants need to be assessed at inclusion of intervention studies to identify the patients most in need of an adherence intervention. Our matched categories may be useful to develop interventions in trials that investigate the effectiveness of adherence interventions. |
format | Online Article Text |
id | pubmed-5107738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-51077382016-11-28 Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework Allemann, Samuel S. Nieuwlaat, Robby van den Bemt, Bart J. F. Hersberger, Kurt E. Arnet, Isabelle Front Pharmacol Pharmacology Introduction: Despite much research, interventions to improve medication adherence report disappointing and inconsistent results. Tailored approaches that match interventions and patient determinants of non-adherence were seldom used in clinical trials. The presence of a multitude of theoretical frameworks and models to categorize interventions and patient determinants complicated the development of common categories shared by interventions and determinants. We retrieved potential interventions and patient determinants from published literature on medication adherence, matched them like locks and keys, and categorized them according to the Theoretical Domains Framework (TDF). Methods: We identified the most relevant literature reviews on interventions and determinants in a pragmatic literature search, extracted all interventions and determinants, grouped similar concepts to umbrella terms and assigned them to TDF categories. All steps were finalized in consensus discussion between the authors. Results: Sixteen articles (5 with determinants, 11 with interventions) were included for analysis. We extracted 103 interventions and 42 determinants that we divided in 26 modifiable and 16 unmodifiable determinants. All interventions and modifiable determinants were matched within 11 categories (Knowledge; Skills; Social/professional role and identity; Beliefs about capabilities; Beliefs about consequences; Intentions; Memory, Attention and decision processes; Environmental context and resources; Social influences; Emotion; and Behavioral regulation). Conclusion: In published trials on medication adherence, the congruence between interventions and determinants can be assessed with matching interventions to determinants. To be successful, interventions in medication adherence should target current modifiable determinants and be tailored to the unmodifiable determinants. Modifiable and unmodifiable determinants need to be assessed at inclusion of intervention studies to identify the patients most in need of an adherence intervention. Our matched categories may be useful to develop interventions in trials that investigate the effectiveness of adherence interventions. Frontiers Media S.A. 2016-11-14 /pmc/articles/PMC5107738/ /pubmed/27895583 http://dx.doi.org/10.3389/fphar.2016.00429 Text en Copyright © 2016 Allemann, Nieuwlaat, van den Bemt, Hersberger and Arnet. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Allemann, Samuel S. Nieuwlaat, Robby van den Bemt, Bart J. F. Hersberger, Kurt E. Arnet, Isabelle Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title | Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title_full | Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title_fullStr | Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title_full_unstemmed | Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title_short | Matching Adherence Interventions to Patient Determinants Using the Theoretical Domains Framework |
title_sort | matching adherence interventions to patient determinants using the theoretical domains framework |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107738/ https://www.ncbi.nlm.nih.gov/pubmed/27895583 http://dx.doi.org/10.3389/fphar.2016.00429 |
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