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Factors Associated with PMTCT Cascade Completion in Four African Countries

Background. Many countries are working to reduce or eliminate mother-to-child transmission (MTCT) of HIV. Prevention efforts have been conceptualized as steps in a cascade but cascade completion rates during and after pregnancy are low. Methods. A cross-sectional survey was performed across 26 commu...

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Autores principales: Dionne-Odom, Jodie, Welty, Thomas K., Westfall, Andrew O., Chi, Benjamin H., Ekouevi, Didier Koumavi, Kasaro, Margaret, Tih, Pius M., Tita, Alan T. N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107823/
https://www.ncbi.nlm.nih.gov/pubmed/27872760
http://dx.doi.org/10.1155/2016/2403936
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author Dionne-Odom, Jodie
Welty, Thomas K.
Westfall, Andrew O.
Chi, Benjamin H.
Ekouevi, Didier Koumavi
Kasaro, Margaret
Tih, Pius M.
Tita, Alan T. N.
author_facet Dionne-Odom, Jodie
Welty, Thomas K.
Westfall, Andrew O.
Chi, Benjamin H.
Ekouevi, Didier Koumavi
Kasaro, Margaret
Tih, Pius M.
Tita, Alan T. N.
author_sort Dionne-Odom, Jodie
collection PubMed
description Background. Many countries are working to reduce or eliminate mother-to-child transmission (MTCT) of HIV. Prevention efforts have been conceptualized as steps in a cascade but cascade completion rates during and after pregnancy are low. Methods. A cross-sectional survey was performed across 26 communities in Cameroon, Cote d'Ivoire, South Africa, and Zambia. Women who reported a pregnancy within two years were enrolled. Participant responses were used to construct the PMTCT cascade with all of the following steps required for completion: at least one antenatal visit, HIV testing performed, HIV testing result received, initiation of maternal prophylaxis, and initiation of infant prophylaxis. Factors associated with cascade completion were identified using multivariable logistic regression modeling. Results. Of 976 HIV-infected women, only 355 (36.4%) completed the PMTCT cascade. Although most women (69.2%) did not know their partner's HIV status; awareness of partner HIV status was associated with cascade completion (aOR 1.4, 95% CI 1.01–2.0). Completion was also associated with receiving an HIV diagnosis prior to pregnancy compared with HIV diagnosis during or after pregnancy (aOR 14.1, 95% CI 5.2–38.6). Conclusions. Pregnant women with HIV infection in Africa who were aware of their partner's HIV status and who were diagnosed with HIV before pregnancy were more likely to complete the PMTCT cascade.
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spelling pubmed-51078232016-11-21 Factors Associated with PMTCT Cascade Completion in Four African Countries Dionne-Odom, Jodie Welty, Thomas K. Westfall, Andrew O. Chi, Benjamin H. Ekouevi, Didier Koumavi Kasaro, Margaret Tih, Pius M. Tita, Alan T. N. AIDS Res Treat Research Article Background. Many countries are working to reduce or eliminate mother-to-child transmission (MTCT) of HIV. Prevention efforts have been conceptualized as steps in a cascade but cascade completion rates during and after pregnancy are low. Methods. A cross-sectional survey was performed across 26 communities in Cameroon, Cote d'Ivoire, South Africa, and Zambia. Women who reported a pregnancy within two years were enrolled. Participant responses were used to construct the PMTCT cascade with all of the following steps required for completion: at least one antenatal visit, HIV testing performed, HIV testing result received, initiation of maternal prophylaxis, and initiation of infant prophylaxis. Factors associated with cascade completion were identified using multivariable logistic regression modeling. Results. Of 976 HIV-infected women, only 355 (36.4%) completed the PMTCT cascade. Although most women (69.2%) did not know their partner's HIV status; awareness of partner HIV status was associated with cascade completion (aOR 1.4, 95% CI 1.01–2.0). Completion was also associated with receiving an HIV diagnosis prior to pregnancy compared with HIV diagnosis during or after pregnancy (aOR 14.1, 95% CI 5.2–38.6). Conclusions. Pregnant women with HIV infection in Africa who were aware of their partner's HIV status and who were diagnosed with HIV before pregnancy were more likely to complete the PMTCT cascade. Hindawi Publishing Corporation 2016 2016-10-31 /pmc/articles/PMC5107823/ /pubmed/27872760 http://dx.doi.org/10.1155/2016/2403936 Text en Copyright © 2016 Jodie Dionne-Odom et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dionne-Odom, Jodie
Welty, Thomas K.
Westfall, Andrew O.
Chi, Benjamin H.
Ekouevi, Didier Koumavi
Kasaro, Margaret
Tih, Pius M.
Tita, Alan T. N.
Factors Associated with PMTCT Cascade Completion in Four African Countries
title Factors Associated with PMTCT Cascade Completion in Four African Countries
title_full Factors Associated with PMTCT Cascade Completion in Four African Countries
title_fullStr Factors Associated with PMTCT Cascade Completion in Four African Countries
title_full_unstemmed Factors Associated with PMTCT Cascade Completion in Four African Countries
title_short Factors Associated with PMTCT Cascade Completion in Four African Countries
title_sort factors associated with pmtct cascade completion in four african countries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107823/
https://www.ncbi.nlm.nih.gov/pubmed/27872760
http://dx.doi.org/10.1155/2016/2403936
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