Modulating endotoxin activity by combinatorial bioengineering of meningococcal lipopolysaccharide

Neisseria meningitidis contains a very potent hexa-acylated LPS that is too toxic for therapeutic applications. We used systematic molecular bioengineering of meningococcal LPS through deletion of biosynthetic enzymes in combination with induction of LPS modifying enzymes to yield a variety of novel...

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Detalles Bibliográficos
Autores principales: Zariri, Afshin, Pupo, Elder, van Riet, Elly, van Putten, Jos P. M., van der Ley, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107901/
https://www.ncbi.nlm.nih.gov/pubmed/27841285
http://dx.doi.org/10.1038/srep36575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107901/
https://www.ncbi.nlm.nih.gov/pubmed/27841285
http://dx.doi.org/10.1038/srep36575

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