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High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya
Kenya is intensifying its national efforts in malaria control to achieve malaria elimination. Detailed characterization of malaria infection among populations living in the areas where the disease is endemic in Kenya is a crucial priority, especially for planning and evaluating future malaria elimin...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107902/ https://www.ncbi.nlm.nih.gov/pubmed/27841361 http://dx.doi.org/10.1038/srep36958 |
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author | Idris, Zulkarnain Md Chan, Chim W. Kongere, James Gitaka, Jesse Logedi, John Omar, Ahmeddin Obonyo, Charles Machini, Beatrice Kemunto Isozumi, Rie Teramoto, Isao Kimura, Masatsugu Kaneko, Akira |
author_facet | Idris, Zulkarnain Md Chan, Chim W. Kongere, James Gitaka, Jesse Logedi, John Omar, Ahmeddin Obonyo, Charles Machini, Beatrice Kemunto Isozumi, Rie Teramoto, Isao Kimura, Masatsugu Kaneko, Akira |
author_sort | Idris, Zulkarnain Md |
collection | PubMed |
description | Kenya is intensifying its national efforts in malaria control to achieve malaria elimination. Detailed characterization of malaria infection among populations living in the areas where the disease is endemic in Kenya is a crucial priority, especially for planning and evaluating future malaria elimination strategy. This study aimed to investigate the distribution and extent of malaria infection on islands in Lake Victoria of Kenya to aid in designing new interventions for malaria elimination. Five cross-sectional surveys were conducted between January 2012 and August 2014 on four islands (Mfangano, Takawiri, Kibuogi and Ngodhe) in Lake Victoria and a coastal mainland (Ungoye). Malaria prevalence varied significantly among settings: highest in Ungoye, followed by the large island of Mfangano and lowest in the three remaining small islands. Of the 3867 malaria infections detected by PCR, 91.8% were asymptomatic, 50.3% were sub-microscopic, of which 94% were also asymptomatic. We observed geographical differences and age dependency in both proportion of sub-microscopic infections and asymptomatic parasite carriage. Our findings highlighted the local heterogeneity in malaria prevalence on islands and a coastal area in Lake Victoria, and provided support for the inclusion of mass drug administration as a component of the intervention package to eliminate malaria on islands. |
format | Online Article Text |
id | pubmed-5107902 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51079022016-11-22 High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya Idris, Zulkarnain Md Chan, Chim W. Kongere, James Gitaka, Jesse Logedi, John Omar, Ahmeddin Obonyo, Charles Machini, Beatrice Kemunto Isozumi, Rie Teramoto, Isao Kimura, Masatsugu Kaneko, Akira Sci Rep Article Kenya is intensifying its national efforts in malaria control to achieve malaria elimination. Detailed characterization of malaria infection among populations living in the areas where the disease is endemic in Kenya is a crucial priority, especially for planning and evaluating future malaria elimination strategy. This study aimed to investigate the distribution and extent of malaria infection on islands in Lake Victoria of Kenya to aid in designing new interventions for malaria elimination. Five cross-sectional surveys were conducted between January 2012 and August 2014 on four islands (Mfangano, Takawiri, Kibuogi and Ngodhe) in Lake Victoria and a coastal mainland (Ungoye). Malaria prevalence varied significantly among settings: highest in Ungoye, followed by the large island of Mfangano and lowest in the three remaining small islands. Of the 3867 malaria infections detected by PCR, 91.8% were asymptomatic, 50.3% were sub-microscopic, of which 94% were also asymptomatic. We observed geographical differences and age dependency in both proportion of sub-microscopic infections and asymptomatic parasite carriage. Our findings highlighted the local heterogeneity in malaria prevalence on islands and a coastal area in Lake Victoria, and provided support for the inclusion of mass drug administration as a component of the intervention package to eliminate malaria on islands. Nature Publishing Group 2016-11-14 /pmc/articles/PMC5107902/ /pubmed/27841361 http://dx.doi.org/10.1038/srep36958 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Idris, Zulkarnain Md Chan, Chim W. Kongere, James Gitaka, Jesse Logedi, John Omar, Ahmeddin Obonyo, Charles Machini, Beatrice Kemunto Isozumi, Rie Teramoto, Isao Kimura, Masatsugu Kaneko, Akira High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title | High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title_full | High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title_fullStr | High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title_full_unstemmed | High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title_short | High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya |
title_sort | high and heterogeneous prevalence of asymptomatic and sub-microscopic malaria infections on islands in lake victoria, kenya |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107902/ https://www.ncbi.nlm.nih.gov/pubmed/27841361 http://dx.doi.org/10.1038/srep36958 |
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