Cerebral Cavernous Malformations: Review of the Genetic and Protein–Protein Interactions Resulting in Disease Pathogenesis

Mutations in the genes KRIT1, CCM2, and PDCD10 are known to result in the formation of cerebral cavernous malformations (CCMs). CCMs are intracranial lesions composed of aberrantly enlarged “cavernous” endothelial channels that can result in cerebral hemorrhage, seizures, and neurologic deficits. Al...

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Detalles Bibliográficos
Autores principales: Baranoski, Jacob F., Kalani, M. Yashar S., Przybylowski, Colin J., Zabramski, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Surgery
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107910/
https://www.ncbi.nlm.nih.gov/pubmed/27896269
http://dx.doi.org/10.3389/fsurg.2016.00060

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