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Hallucinations and conscious access to visual inputs in Parkinson’s disease
The pathophysiology of visual hallucinations in Parkinson’s disease has yet to be characterized. Although stimulus-driven (“bottom-up”) processes are known to be impaired, the role of “top-down” processes remains to be determined. Distinguishing between conscious and non-conscious detections (i.e. a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107911/ https://www.ncbi.nlm.nih.gov/pubmed/27841268 http://dx.doi.org/10.1038/srep36284 |
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author | Lefebvre, Stéphanie Baille, Guillaume Jardri, Renaud Plomhause, Lucie Szaffarczyk, Sébastien Defebvre, Luc Thomas, Pierre Delmaire, Christine Pins, Delphine Dujardin, Kathy |
author_facet | Lefebvre, Stéphanie Baille, Guillaume Jardri, Renaud Plomhause, Lucie Szaffarczyk, Sébastien Defebvre, Luc Thomas, Pierre Delmaire, Christine Pins, Delphine Dujardin, Kathy |
author_sort | Lefebvre, Stéphanie |
collection | PubMed |
description | The pathophysiology of visual hallucinations in Parkinson’s disease has yet to be characterized. Although stimulus-driven (“bottom-up”) processes are known to be impaired, the role of “top-down” processes remains to be determined. Distinguishing between conscious and non-conscious detections (i.e. access to consciousness) may be a valuable way of monitoring top-down processes. Conscious access to visual inputs was investigated to identify the neural substrates underlying susceptibility to hallucinations in Parkinson’s disease. Seventeen healthy controls, 18 Parkinson’s disease patients with minor visual hallucinations and 16 without were enrolled in the study. During functional magnetic resonance imaging, the participants performed a visual detection task. The detection threshold was significantly higher in each patient group than in healthy controls while the two groups of patients did not differ significantly. Compared with hallucination-free patients, patients with minor hallucinations displayed hyperactivation of prefrontal and right occipital cortices, and hypoactivation of the left cingulate, temporal and occipital cortices. During conscious access to visual inputs, the functional network in patients with visual hallucinations differed from that seen in patients without visual hallucinations. This suggests that the supremacy of top-down processes in visual information processing may enhance susceptibility to hallucinations in Parkinson’s disease. |
format | Online Article Text |
id | pubmed-5107911 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51079112016-11-22 Hallucinations and conscious access to visual inputs in Parkinson’s disease Lefebvre, Stéphanie Baille, Guillaume Jardri, Renaud Plomhause, Lucie Szaffarczyk, Sébastien Defebvre, Luc Thomas, Pierre Delmaire, Christine Pins, Delphine Dujardin, Kathy Sci Rep Article The pathophysiology of visual hallucinations in Parkinson’s disease has yet to be characterized. Although stimulus-driven (“bottom-up”) processes are known to be impaired, the role of “top-down” processes remains to be determined. Distinguishing between conscious and non-conscious detections (i.e. access to consciousness) may be a valuable way of monitoring top-down processes. Conscious access to visual inputs was investigated to identify the neural substrates underlying susceptibility to hallucinations in Parkinson’s disease. Seventeen healthy controls, 18 Parkinson’s disease patients with minor visual hallucinations and 16 without were enrolled in the study. During functional magnetic resonance imaging, the participants performed a visual detection task. The detection threshold was significantly higher in each patient group than in healthy controls while the two groups of patients did not differ significantly. Compared with hallucination-free patients, patients with minor hallucinations displayed hyperactivation of prefrontal and right occipital cortices, and hypoactivation of the left cingulate, temporal and occipital cortices. During conscious access to visual inputs, the functional network in patients with visual hallucinations differed from that seen in patients without visual hallucinations. This suggests that the supremacy of top-down processes in visual information processing may enhance susceptibility to hallucinations in Parkinson’s disease. Nature Publishing Group 2016-11-14 /pmc/articles/PMC5107911/ /pubmed/27841268 http://dx.doi.org/10.1038/srep36284 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Lefebvre, Stéphanie Baille, Guillaume Jardri, Renaud Plomhause, Lucie Szaffarczyk, Sébastien Defebvre, Luc Thomas, Pierre Delmaire, Christine Pins, Delphine Dujardin, Kathy Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title | Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title_full | Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title_fullStr | Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title_full_unstemmed | Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title_short | Hallucinations and conscious access to visual inputs in Parkinson’s disease |
title_sort | hallucinations and conscious access to visual inputs in parkinson’s disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107911/ https://www.ncbi.nlm.nih.gov/pubmed/27841268 http://dx.doi.org/10.1038/srep36284 |
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