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Tomato consumption and prostate cancer risk: a systematic review and meta-analysis
Previous studies have reported controversial results on the association between tomato consumption and prostate cancer risk. Hence, we performed a meta-analysis to comprehensively evaluate this relationship. A total of 24 published studies with 15,099 cases were included. Relative risks (RR) and 95%...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107915/ https://www.ncbi.nlm.nih.gov/pubmed/27841367 http://dx.doi.org/10.1038/srep37091 |
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author | Xu, Xin Li, Jiangfeng Wang, Xiao Wang, Song Meng, Shuai Zhu, Yi Liang, Zhen Zheng, Xiangyi Xie, Liping |
author_facet | Xu, Xin Li, Jiangfeng Wang, Xiao Wang, Song Meng, Shuai Zhu, Yi Liang, Zhen Zheng, Xiangyi Xie, Liping |
author_sort | Xu, Xin |
collection | PubMed |
description | Previous studies have reported controversial results on the association between tomato consumption and prostate cancer risk. Hence, we performed a meta-analysis to comprehensively evaluate this relationship. A total of 24 published studies with 15,099 cases were included. Relative risks (RR) and 95% confidence intervals (CI) were pooled with a random-effects model. Tomato intake was associated with a reduced risk of prostate cancer (RR 0.86, 95% CI 0.75–0.98, P = 0.019; P < 0.001 for heterogeneity, I(2) = 72.7%). When stratified by study design, the RRs for case-control and cohort studies were 0.76 (95% CI 0.61–0.94, P = 0.010) and 0.96 (95% CI 0.84–1.10, P = 0.579), respectively. In the subgroup analysis by geographical region, significant protective effects were observed in Asian (RR 0.43, 95% CI 0.22–0.85, P = 0.015) and Oceania populations (RR 0.81, 95% CI 0.67–0.99, P = 0.035), but not in other geographical populations. Begg’s test indicated a significant publication bias (P = 0.015). Overall, tomato intake may have a weak protective effect against prostate cancer. Because of the huge heterogeneity and null results in cohort studies, further prospective studies are needed to explore the potential relationship between tomato consumption and prostate cancer risk. |
format | Online Article Text |
id | pubmed-5107915 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51079152016-11-22 Tomato consumption and prostate cancer risk: a systematic review and meta-analysis Xu, Xin Li, Jiangfeng Wang, Xiao Wang, Song Meng, Shuai Zhu, Yi Liang, Zhen Zheng, Xiangyi Xie, Liping Sci Rep Article Previous studies have reported controversial results on the association between tomato consumption and prostate cancer risk. Hence, we performed a meta-analysis to comprehensively evaluate this relationship. A total of 24 published studies with 15,099 cases were included. Relative risks (RR) and 95% confidence intervals (CI) were pooled with a random-effects model. Tomato intake was associated with a reduced risk of prostate cancer (RR 0.86, 95% CI 0.75–0.98, P = 0.019; P < 0.001 for heterogeneity, I(2) = 72.7%). When stratified by study design, the RRs for case-control and cohort studies were 0.76 (95% CI 0.61–0.94, P = 0.010) and 0.96 (95% CI 0.84–1.10, P = 0.579), respectively. In the subgroup analysis by geographical region, significant protective effects were observed in Asian (RR 0.43, 95% CI 0.22–0.85, P = 0.015) and Oceania populations (RR 0.81, 95% CI 0.67–0.99, P = 0.035), but not in other geographical populations. Begg’s test indicated a significant publication bias (P = 0.015). Overall, tomato intake may have a weak protective effect against prostate cancer. Because of the huge heterogeneity and null results in cohort studies, further prospective studies are needed to explore the potential relationship between tomato consumption and prostate cancer risk. Nature Publishing Group 2016-11-14 /pmc/articles/PMC5107915/ /pubmed/27841367 http://dx.doi.org/10.1038/srep37091 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Xu, Xin Li, Jiangfeng Wang, Xiao Wang, Song Meng, Shuai Zhu, Yi Liang, Zhen Zheng, Xiangyi Xie, Liping Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title | Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title_full | Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title_fullStr | Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title_full_unstemmed | Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title_short | Tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
title_sort | tomato consumption and prostate cancer risk: a systematic review and meta-analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107915/ https://www.ncbi.nlm.nih.gov/pubmed/27841367 http://dx.doi.org/10.1038/srep37091 |
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