Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle

Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography....

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Autores principales: Li, Yong, Liu, Yun-Bao, Yan, Hui-Min, Liu, Yang-Lan, Li, Yu-Huan, Lv, Hai-Ning, Ma, Shuang-Gang, Qu, Jing, Yu, Shi-Shan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107939/
https://www.ncbi.nlm.nih.gov/pubmed/27841292
http://dx.doi.org/10.1038/srep36752
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author Li, Yong
Liu, Yun-Bao
Yan, Hui-Min
Liu, Yang-Lan
Li, Yu-Huan
Lv, Hai-Ning
Ma, Shuang-Gang
Qu, Jing
Yu, Shi-Shan
author_facet Li, Yong
Liu, Yun-Bao
Yan, Hui-Min
Liu, Yang-Lan
Li, Yu-Huan
Lv, Hai-Ning
Ma, Shuang-Gang
Qu, Jing
Yu, Shi-Shan
author_sort Li, Yong
collection PubMed
description Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography. Rhodomollin B (2) exhibited modest activity against influenza virus A/95-359, with an IC(50) value of 19.24 μM.
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spelling pubmed-51079392016-11-22 Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle Li, Yong Liu, Yun-Bao Yan, Hui-Min Liu, Yang-Lan Li, Yu-Huan Lv, Hai-Ning Ma, Shuang-Gang Qu, Jing Yu, Shi-Shan Sci Rep Article Two new grayanoids, rhodomollin A (1) and rhodomollin B (2), possessing an unprecedented D-homo grayanane carbon skeleton, were isolated from the fruits of Rhododendron molle. The structures of 1 and 2 were fully characterized using a combination of spectroscopic analyses and X-ray crystallography. Rhodomollin B (2) exhibited modest activity against influenza virus A/95-359, with an IC(50) value of 19.24 μM. Nature Publishing Group 2016-11-14 /pmc/articles/PMC5107939/ /pubmed/27841292 http://dx.doi.org/10.1038/srep36752 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Li, Yong
Liu, Yun-Bao
Yan, Hui-Min
Liu, Yang-Lan
Li, Yu-Huan
Lv, Hai-Ning
Ma, Shuang-Gang
Qu, Jing
Yu, Shi-Shan
Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title_full Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title_fullStr Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title_full_unstemmed Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title_short Rhodomollins A and B, two Diterpenoids with an Unprecedented Backbone from the Fruits of Rhododendron molle
title_sort rhodomollins a and b, two diterpenoids with an unprecedented backbone from the fruits of rhododendron molle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107939/
https://www.ncbi.nlm.nih.gov/pubmed/27841292
http://dx.doi.org/10.1038/srep36752
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