High Hepsin expression predicts poor prognosis in Gastric Cancer

Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Mingming, Zhao, Junjie, Tang, Wenyi, Wang, Yanru, Peng, Peike, Li, Lili, Song, Shushu, Wu, Hao, Li, Can, Yang, Caiting, Wang, Xuefei, Zhang, Chunyi, Gu, Jianxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107942/
https://www.ncbi.nlm.nih.gov/pubmed/27841306
http://dx.doi.org/10.1038/srep36902
_version_ 1782467283582451712
author Zhang, Mingming
Zhao, Junjie
Tang, Wenyi
Wang, Yanru
Peng, Peike
Li, Lili
Song, Shushu
Wu, Hao
Li, Can
Yang, Caiting
Wang, Xuefei
Zhang, Chunyi
Gu, Jianxin
author_facet Zhang, Mingming
Zhao, Junjie
Tang, Wenyi
Wang, Yanru
Peng, Peike
Li, Lili
Song, Shushu
Wu, Hao
Li, Can
Yang, Caiting
Wang, Xuefei
Zhang, Chunyi
Gu, Jianxin
author_sort Zhang, Mingming
collection PubMed
description Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer.
format Online
Article
Text
id pubmed-5107942
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-51079422016-11-22 High Hepsin expression predicts poor prognosis in Gastric Cancer Zhang, Mingming Zhao, Junjie Tang, Wenyi Wang, Yanru Peng, Peike Li, Lili Song, Shushu Wu, Hao Li, Can Yang, Caiting Wang, Xuefei Zhang, Chunyi Gu, Jianxin Sci Rep Article Hepsin, a membrane-associated serine protease, is frequently upregulated in epithelial cancers and involved in cancer progression. Our study aims to describe the expression pattern and evaluate the clinical implication of hepsin in gastric cancer patients. The mRNA expression of hepsin was analyzed in 50 gastric cancer and matched non-tumor tissues, which was downregulated in 78% (39/50) of gastric cancer. By searching and analyzing four independent datasets from Oncomine, we obtained the similar results. Furthermore, we evaluated the hepsin expression by IHC in tissue microarray (TMA) containing 220 Gastric Cancer specimens. More importantly, Kaplan-Meier survival and Cox regression analyses were taken to access the prognosis of gastric cancer and predicted that hepsin protein expression was one of the significant and independent prognostic factors for overall survival of Gastric Cancer. Nature Publishing Group 2016-11-14 /pmc/articles/PMC5107942/ /pubmed/27841306 http://dx.doi.org/10.1038/srep36902 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Mingming
Zhao, Junjie
Tang, Wenyi
Wang, Yanru
Peng, Peike
Li, Lili
Song, Shushu
Wu, Hao
Li, Can
Yang, Caiting
Wang, Xuefei
Zhang, Chunyi
Gu, Jianxin
High Hepsin expression predicts poor prognosis in Gastric Cancer
title High Hepsin expression predicts poor prognosis in Gastric Cancer
title_full High Hepsin expression predicts poor prognosis in Gastric Cancer
title_fullStr High Hepsin expression predicts poor prognosis in Gastric Cancer
title_full_unstemmed High Hepsin expression predicts poor prognosis in Gastric Cancer
title_short High Hepsin expression predicts poor prognosis in Gastric Cancer
title_sort high hepsin expression predicts poor prognosis in gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107942/
https://www.ncbi.nlm.nih.gov/pubmed/27841306
http://dx.doi.org/10.1038/srep36902
work_keys_str_mv AT zhangmingming highhepsinexpressionpredictspoorprognosisingastriccancer
AT zhaojunjie highhepsinexpressionpredictspoorprognosisingastriccancer
AT tangwenyi highhepsinexpressionpredictspoorprognosisingastriccancer
AT wangyanru highhepsinexpressionpredictspoorprognosisingastriccancer
AT pengpeike highhepsinexpressionpredictspoorprognosisingastriccancer
AT lilili highhepsinexpressionpredictspoorprognosisingastriccancer
AT songshushu highhepsinexpressionpredictspoorprognosisingastriccancer
AT wuhao highhepsinexpressionpredictspoorprognosisingastriccancer
AT lican highhepsinexpressionpredictspoorprognosisingastriccancer
AT yangcaiting highhepsinexpressionpredictspoorprognosisingastriccancer
AT wangxuefei highhepsinexpressionpredictspoorprognosisingastriccancer
AT zhangchunyi highhepsinexpressionpredictspoorprognosisingastriccancer
AT gujianxin highhepsinexpressionpredictspoorprognosisingastriccancer

Ejemplares similares