TRF1 phosphorylation on T271 modulates telomerase-dependent telomere length maintenance as well as the formation of ALT-associated PML bodies

TRF1, a component of the shelterin complex, plays a key role in both telomerase-dependent telomere maintenance and alternative lengthening of telomeres, the latter also known as ALT. Characteristics of ALT cells include C-circles and ALT-associated PML bodies, referred to as APBs. The function of TR...

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Detalles Bibliográficos
Autores principales: Ho, Angus, Wilson, Florence R., Peragine, Stephanie L., Jeyanthan, Kajaparan, Mitchell, Taylor R. H., Zhu, Xu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107961/
https://www.ncbi.nlm.nih.gov/pubmed/27841304
http://dx.doi.org/10.1038/srep36913

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