The sensitivity of the DNA damage checkpoint prevents oocyte maturation in endometriosis

Mouse oocytes respond to DNA damage by arresting in meiosis I through activity of the Spindle Assembly Checkpoint (SAC) and DNA Damage Response (DDR) pathways. It is currently not known if DNA damage is the primary trigger for arrest, or if the pathway is sensitive to levels of DNA damage experience...

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Detalles Bibliográficos
Autores principales: Hamdan, Mukhri, Jones, Keith T., Cheong, Ying, Lane, Simon I. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107963/
https://www.ncbi.nlm.nih.gov/pubmed/27841311
http://dx.doi.org/10.1038/srep36994

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