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Hematological complications in anorexia nervosa
BACKGROUND/OBJECTIVES: Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective study on the prevalence of these disorders in a large cohort of 318 fe...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107965/ https://www.ncbi.nlm.nih.gov/pubmed/27436150 http://dx.doi.org/10.1038/ejcn.2016.115 |
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author | De Filippo, E Marra, M Alfinito, F Di Guglielmo, M L Majorano, P Cerciello, G De Caprio, C Contaldo, F Pasanisi, F |
author_facet | De Filippo, E Marra, M Alfinito, F Di Guglielmo, M L Majorano, P Cerciello, G De Caprio, C Contaldo, F Pasanisi, F |
author_sort | De Filippo, E |
collection | PubMed |
description | BACKGROUND/OBJECTIVES: Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective study on the prevalence of these disorders in a large cohort of 318 female patients with AN (20.4±5.6 years, body mass index (BMI) 15.9±1.6 kg/m(2)), recruited in the Outpatient Unit for Malnutrition secondary to Eating Disorders at the Department of Clinical Medicine and Surgery, Federico II University Hospital, since February 1991 to December 2012. SUBJECTS/METHODS: Patients were studied on an outpatient basis after obtaining medical history, clinical examination, routine hematobiochemical and endocrine tests, electrocardiography, psychiatric interview and bioelectrical impedance analysis and, in particular, phase angle determination. All patients with other comorbidities, in particular with mean corpuscular volume <80 fl, were excluded for suspected genetic alteration in the synthesis of hemoglobin. RESULTS: Hematologic data showed that 16.7% of patients had anemia, 7.9% neutropenia and 8.9% thrombocytopenia. These abnormalities were strictly related to the duration of illness (P=0.028), and to protein energy malnutrition, in particular, BMI and phase angle (P<0.001). CONCLUSIONS: Our study offers description of the incidence of hematologic defects in a selected and large sample of AN female patients, suggesting that its incidence is related to the degree and duration of protein energy malnutrition. |
format | Online Article Text |
id | pubmed-5107965 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51079652016-11-18 Hematological complications in anorexia nervosa De Filippo, E Marra, M Alfinito, F Di Guglielmo, M L Majorano, P Cerciello, G De Caprio, C Contaldo, F Pasanisi, F Eur J Clin Nutr Original Article BACKGROUND/OBJECTIVES: Anemia, leukopenia and, although less frequently, thrombocytopenia are possible hematological complications of anorexia nervosa considered strictly secondary to chronic malnutrition. This is a retrospective study on the prevalence of these disorders in a large cohort of 318 female patients with AN (20.4±5.6 years, body mass index (BMI) 15.9±1.6 kg/m(2)), recruited in the Outpatient Unit for Malnutrition secondary to Eating Disorders at the Department of Clinical Medicine and Surgery, Federico II University Hospital, since February 1991 to December 2012. SUBJECTS/METHODS: Patients were studied on an outpatient basis after obtaining medical history, clinical examination, routine hematobiochemical and endocrine tests, electrocardiography, psychiatric interview and bioelectrical impedance analysis and, in particular, phase angle determination. All patients with other comorbidities, in particular with mean corpuscular volume <80 fl, were excluded for suspected genetic alteration in the synthesis of hemoglobin. RESULTS: Hematologic data showed that 16.7% of patients had anemia, 7.9% neutropenia and 8.9% thrombocytopenia. These abnormalities were strictly related to the duration of illness (P=0.028), and to protein energy malnutrition, in particular, BMI and phase angle (P<0.001). CONCLUSIONS: Our study offers description of the incidence of hematologic defects in a selected and large sample of AN female patients, suggesting that its incidence is related to the degree and duration of protein energy malnutrition. Nature Publishing Group 2016-11 2016-07-20 /pmc/articles/PMC5107965/ /pubmed/27436150 http://dx.doi.org/10.1038/ejcn.2016.115 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Original Article De Filippo, E Marra, M Alfinito, F Di Guglielmo, M L Majorano, P Cerciello, G De Caprio, C Contaldo, F Pasanisi, F Hematological complications in anorexia nervosa |
title | Hematological complications in anorexia nervosa |
title_full | Hematological complications in anorexia nervosa |
title_fullStr | Hematological complications in anorexia nervosa |
title_full_unstemmed | Hematological complications in anorexia nervosa |
title_short | Hematological complications in anorexia nervosa |
title_sort | hematological complications in anorexia nervosa |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107965/ https://www.ncbi.nlm.nih.gov/pubmed/27436150 http://dx.doi.org/10.1038/ejcn.2016.115 |
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