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HIV-1 Nef sequesters MHC-I intracellularly by targeting early stages of endocytosis and recycling

A defining characteristic of HIV-1 infection is the ability of the virus to persist within the host. Specifically, MHC-I downregulation by the HIV-1 accessory protein Nef is of critical importance in preventing infected cells from cytotoxic T-cell mediated killing. Nef downregulates MHC-I by modulat...

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Detalles Bibliográficos
Autores principales:	Dirk, Brennan S., Pawlak, Emily N., Johnson, Aaron L., Van Nynatten, Logan R., Jacob, Rajesh A., Heit, Bryan, Dikeakos, Jimmy D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107982/ https://www.ncbi.nlm.nih.gov/pubmed/27841315 http://dx.doi.org/10.1038/srep37021

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