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Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9

Progressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISP...

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Detalles Bibliográficos
Autores principales:	Chou, Yi-ying, Krupp, Annabel, Kaynor, Campbell, Gaudin, Raphaël, Ma, Minghe, Cahir-McFarland, Ellen, Kirchhausen, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107994/ https://www.ncbi.nlm.nih.gov/pubmed/27841295 http://dx.doi.org/10.1038/srep36921

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