Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation

Our previous studies have demonstrated functional protein–protein interactions between cytochrome P450 (CYP) 3A and UDP-glucuronosyltransferase (UGT). However, the role of carbohydrate chains of UGTs in the interaction with CYP is not well understood. To address this issue, we examined whether CYP3A...

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Detalles Bibliográficos
Autores principales: Nakamura, Tatsuro, Yamaguchi, Naho, Miyauchi, Yuu, Takeda, Tomoki, Yamazoe, Yasushi, Nagata, Kiyoshi, Mackenzie, Peter I., Yamada, Hideyuki, Ishii, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5107996/
https://www.ncbi.nlm.nih.gov/pubmed/27895582
http://dx.doi.org/10.3389/fphar.2016.00427

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