Heterogeneous response and progression patterns reveal phenotypic heterogeneity of tyrosine kinase inhibitor response in metastatic renal cell carcinoma

BACKGROUND: Molecular intratumour heterogeneity (ITH) is common in clear cell renal carcinomas (ccRCCs). However, it remains unknown whether this is mirrored by heterogeneity of drug responses between metastases in the same patient. METHODS: We performed a retrospective central radiological analysis...

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Detalles Bibliográficos
Autores principales: Crusz, Shanthini M., Tang, Yen Zhi, Sarker, Shah-Jalal, Prevoo, Warner, Kiyani, Irfan, Beltran, Luis, Peters, John, Sahdev, Anju, Bex, Axel, Powles, Thomas, Gerlinger, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108081/
https://www.ncbi.nlm.nih.gov/pubmed/27842541
http://dx.doi.org/10.1186/s12916-016-0729-9

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