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Possible role of elevated serum testosterone in pathogenesis of renal stone formation
BACKGROUND: Urolithiasis or renal stone formation occurs with three times higher frequency in males and decreases with age in parallel with the serum testosterone levels, suggesting a role played by male sex hormones. Androgens appear a promotion action and estrogens an inhibitory action on kidney s...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108098/ https://www.ncbi.nlm.nih.gov/pubmed/27857889 http://dx.doi.org/10.4103/2229-516X.192593 |
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author | Gupta, Kapil Gill, Gurpreet Singh Mahajan, Rajiv |
author_facet | Gupta, Kapil Gill, Gurpreet Singh Mahajan, Rajiv |
author_sort | Gupta, Kapil |
collection | PubMed |
description | BACKGROUND: Urolithiasis or renal stone formation occurs with three times higher frequency in males and decreases with age in parallel with the serum testosterone levels, suggesting a role played by male sex hormones. Androgens appear a promotion action and estrogens an inhibitory action on kidney stone formation in several animal models suggesting a study to be carried out to deduce the role played by serum testosterone in the formation of renal stones. AIM: The aim of this study is to define the involvement of serum total testosterone, free testosterone, and dihydrotestosterone in the pathogenesis of urolithiasis in males by comparing the results with healthy males with no present or past history of urolithiasis as controls. MATERIALS AND METHODS: A case–control study was undertaken with 108 participants: 78 males diagnosed with urolithiasis and 30 age-matched healthy males. RESULTS: The difference between mean age and body mass index of patients and controls were found to be nonsignificant. The total serum testosterone levels, serum dihydrotestosterone levels, were found to be higher in patients when compared to controls, and the difference was found to be significant. The levels of free testosterone and serum estradiol were also found to be higher in urolithiatic patients. CONCLUSION: The study demonstrates that elevated levels of serum testosterone and serum dihydrotestosterone might be involved in increased incidences of stone formation. The higher levels of estradiol do not seem to be a protective factor in males with urolithiasis with higher serum testosterone levels. |
format | Online Article Text |
id | pubmed-5108098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51080982016-11-17 Possible role of elevated serum testosterone in pathogenesis of renal stone formation Gupta, Kapil Gill, Gurpreet Singh Mahajan, Rajiv Int J Appl Basic Med Res Original Article BACKGROUND: Urolithiasis or renal stone formation occurs with three times higher frequency in males and decreases with age in parallel with the serum testosterone levels, suggesting a role played by male sex hormones. Androgens appear a promotion action and estrogens an inhibitory action on kidney stone formation in several animal models suggesting a study to be carried out to deduce the role played by serum testosterone in the formation of renal stones. AIM: The aim of this study is to define the involvement of serum total testosterone, free testosterone, and dihydrotestosterone in the pathogenesis of urolithiasis in males by comparing the results with healthy males with no present or past history of urolithiasis as controls. MATERIALS AND METHODS: A case–control study was undertaken with 108 participants: 78 males diagnosed with urolithiasis and 30 age-matched healthy males. RESULTS: The difference between mean age and body mass index of patients and controls were found to be nonsignificant. The total serum testosterone levels, serum dihydrotestosterone levels, were found to be higher in patients when compared to controls, and the difference was found to be significant. The levels of free testosterone and serum estradiol were also found to be higher in urolithiatic patients. CONCLUSION: The study demonstrates that elevated levels of serum testosterone and serum dihydrotestosterone might be involved in increased incidences of stone formation. The higher levels of estradiol do not seem to be a protective factor in males with urolithiasis with higher serum testosterone levels. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5108098/ /pubmed/27857889 http://dx.doi.org/10.4103/2229-516X.192593 Text en Copyright: © 2016 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Gupta, Kapil Gill, Gurpreet Singh Mahajan, Rajiv Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title | Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title_full | Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title_fullStr | Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title_full_unstemmed | Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title_short | Possible role of elevated serum testosterone in pathogenesis of renal stone formation |
title_sort | possible role of elevated serum testosterone in pathogenesis of renal stone formation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108098/ https://www.ncbi.nlm.nih.gov/pubmed/27857889 http://dx.doi.org/10.4103/2229-516X.192593 |
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