Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children

We have explored the added value of interferon-γ (IFNγ)–inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased...

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Detalles Bibliográficos
Autores principales: Jenum, Synne, Dhanasekaran, Sivakumaran, Ritz, Christian, Macaden, Ragini, Doherty, T. Mark, Grewal, Harleen M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Williams & Wilkins 2016
Materias:
Immunology Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108305/
https://www.ncbi.nlm.nih.gov/pubmed/27642776
http://dx.doi.org/10.1097/INF.0000000000001328
Descripción
Sumario:We have explored the added value of interferon-γ (IFNγ)–inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.

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