Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children

We have explored the added value of interferon-γ (IFNγ)–inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased...

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Detalles Bibliográficos
Autores principales: Jenum, Synne, Dhanasekaran, Sivakumaran, Ritz, Christian, Macaden, Ragini, Doherty, T. Mark, Grewal, Harleen M. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Williams & Wilkins 2016
Materias:
Immunology Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108305/
https://www.ncbi.nlm.nih.gov/pubmed/27642776
http://dx.doi.org/10.1097/INF.0000000000001328
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author Jenum, Synne
Dhanasekaran, Sivakumaran
Ritz, Christian
Macaden, Ragini
Doherty, T. Mark
Grewal, Harleen M. S.
author_facet Jenum, Synne
Dhanasekaran, Sivakumaran
Ritz, Christian
Macaden, Ragini
Doherty, T. Mark
Grewal, Harleen M. S.
author_sort Jenum, Synne
collection PubMed
description We have explored the added value of interferon-γ (IFNγ)–inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays.
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spelling pubmed-51083052016-11-23 Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children Jenum, Synne Dhanasekaran, Sivakumaran Ritz, Christian Macaden, Ragini Doherty, T. Mark Grewal, Harleen M. S. Pediatr Infect Dis J Immunology Reports We have explored the added value of interferon-γ (IFNγ)–inducible protein 10 as a read-out of Mycobacterium tuberculosis–specific immunity in young Indian children, where the sensitivity of the IFNγ release assays for tuberculosis is poor. Reduced frequency of indeterminate results and an increased sensitivity for tuberculosis suggest a potential for fewer missed cases with a combined IFNγ/inducible protein 10 read-out in a 4th generation IFNγ release assays. Williams & Wilkins 2016-12 2016-11-11 /pmc/articles/PMC5108305/ /pubmed/27642776 http://dx.doi.org/10.1097/INF.0000000000001328 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Immunology Reports
Jenum, Synne
Dhanasekaran, Sivakumaran
Ritz, Christian
Macaden, Ragini
Doherty, T. Mark
Grewal, Harleen M. S.
Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title_full Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title_fullStr Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title_full_unstemmed Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title_short Added Value of IP-10 as a Read-Out of Mycobacterium tuberculosis: Specific Immunity in Young Children
title_sort added value of ip-10 as a read-out of mycobacterium tuberculosis: specific immunity in young children
topic Immunology Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108305/
https://www.ncbi.nlm.nih.gov/pubmed/27642776
http://dx.doi.org/10.1097/INF.0000000000001328
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