Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity

Doxorubicin (Dox) could trigger a large amount of apoptotic cells in the myocardium, which leads to dilated cardiomyopathy and heart failure. S-propargyl-cysteine (SPRC), a producing agent of endogenous hydrogen sulfide (H(2)S), possesses cardioprotective efficacy. However, the specific effect and m...

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Detalles Bibliográficos
Autores principales: Wu, J, Guo, W, Lin, S-Z, Wang, Z-J, Kan, J-T, Chen, S-Y, Zhu, Y-Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108313/
https://www.ncbi.nlm.nih.gov/pubmed/27537522
http://dx.doi.org/10.1038/cddis.2016.209

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