MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL

Pro-survival BCL-2 family members protect cells from programmed cell death that can be induced by multiple internal or external cues. Within the haematopoietic lineages, the BCL-2 family members BCL-2, BCL-XL and MCL-1 are known to support cell survival but the individual and overlapping roles of th...

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Detalles Bibliográficos
Autores principales: Vikström, Ingela B, Slomp, Anne, Carrington, Emma M, Moesbergen, Laura M, Chang, Catherine, Kelly, Gemma L, Glaser, Stefan P, Jansen, J H Marco, Leusen, Jeanette H W, Strasser, Andreas, Huang, David C S, Lew, Andrew M, Peperzak, Victor, Tarlinton, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108322/
https://www.ncbi.nlm.nih.gov/pubmed/27560714
http://dx.doi.org/10.1038/cddis.2016.237

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