Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

To identify risk variants for multiple myeloma (MM), we conducted a genome-wide association study totaling of 1,675 MM cases and 5,903 controls. We identified risk loci for MM at 3p22.1 (rs1052501, ULK4; odds ratio [OR]=1.32; P=7.47x10(-9)) and 7p15.3 (rs4487645, OR=1.38; P=3.33x10(-15)). In additio...

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Autores principales: Broderick, Peter, Chubb, Daniel, Johnson, David C, Weinhold, Niels, Försti, Asta, Lloyd, Amy, Olver, Bianca, Ma, Yussanne, Dobbins, Sara E, Walker, Brian A, Davies, Faith E, Gregory, Walter A, Childs, J. Anthony, Ross, Fiona M, Jackson, Graham H, Neben, Kai, Jauch, Anna, Hoffmann, Per, Mühleisen, Thomas W, Nöthen, Markus M, Moebus, Susanne, Tomlinson, Ian P, Goldschmidt, Hartmut, Hemminki, Kari, Morgan, Gareth J, Houlston, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108406/
https://www.ncbi.nlm.nih.gov/pubmed/22120009
http://dx.doi.org/10.1038/ng.993
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author Broderick, Peter
Chubb, Daniel
Johnson, David C
Weinhold, Niels
Försti, Asta
Lloyd, Amy
Olver, Bianca
Ma, Yussanne
Dobbins, Sara E
Walker, Brian A
Davies, Faith E
Gregory, Walter A
Childs, J. Anthony
Ross, Fiona M
Jackson, Graham H
Neben, Kai
Jauch, Anna
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Tomlinson, Ian P
Goldschmidt, Hartmut
Hemminki, Kari
Morgan, Gareth J
Houlston, Richard S
author_facet Broderick, Peter
Chubb, Daniel
Johnson, David C
Weinhold, Niels
Försti, Asta
Lloyd, Amy
Olver, Bianca
Ma, Yussanne
Dobbins, Sara E
Walker, Brian A
Davies, Faith E
Gregory, Walter A
Childs, J. Anthony
Ross, Fiona M
Jackson, Graham H
Neben, Kai
Jauch, Anna
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Tomlinson, Ian P
Goldschmidt, Hartmut
Hemminki, Kari
Morgan, Gareth J
Houlston, Richard S
author_sort Broderick, Peter
collection PubMed
description To identify risk variants for multiple myeloma (MM), we conducted a genome-wide association study totaling of 1,675 MM cases and 5,903 controls. We identified risk loci for MM at 3p22.1 (rs1052501, ULK4; odds ratio [OR]=1.32; P=7.47x10(-9)) and 7p15.3 (rs4487645, OR=1.38; P=3.33x10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR=1.29; P=1.22x10(-7)). Our study reports previously unidentified genomic regions associated with MM risk that may lead to new etiological insights.
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spelling pubmed-51084062016-11-14 Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk Broderick, Peter Chubb, Daniel Johnson, David C Weinhold, Niels Försti, Asta Lloyd, Amy Olver, Bianca Ma, Yussanne Dobbins, Sara E Walker, Brian A Davies, Faith E Gregory, Walter A Childs, J. Anthony Ross, Fiona M Jackson, Graham H Neben, Kai Jauch, Anna Hoffmann, Per Mühleisen, Thomas W Nöthen, Markus M Moebus, Susanne Tomlinson, Ian P Goldschmidt, Hartmut Hemminki, Kari Morgan, Gareth J Houlston, Richard S Nat Genet Article To identify risk variants for multiple myeloma (MM), we conducted a genome-wide association study totaling of 1,675 MM cases and 5,903 controls. We identified risk loci for MM at 3p22.1 (rs1052501, ULK4; odds ratio [OR]=1.32; P=7.47x10(-9)) and 7p15.3 (rs4487645, OR=1.38; P=3.33x10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR=1.29; P=1.22x10(-7)). Our study reports previously unidentified genomic regions associated with MM risk that may lead to new etiological insights. 2011-11-27 /pmc/articles/PMC5108406/ /pubmed/22120009 http://dx.doi.org/10.1038/ng.993 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Broderick, Peter
Chubb, Daniel
Johnson, David C
Weinhold, Niels
Försti, Asta
Lloyd, Amy
Olver, Bianca
Ma, Yussanne
Dobbins, Sara E
Walker, Brian A
Davies, Faith E
Gregory, Walter A
Childs, J. Anthony
Ross, Fiona M
Jackson, Graham H
Neben, Kai
Jauch, Anna
Hoffmann, Per
Mühleisen, Thomas W
Nöthen, Markus M
Moebus, Susanne
Tomlinson, Ian P
Goldschmidt, Hartmut
Hemminki, Kari
Morgan, Gareth J
Houlston, Richard S
Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title_full Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title_fullStr Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title_full_unstemmed Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title_short Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
title_sort common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108406/
https://www.ncbi.nlm.nih.gov/pubmed/22120009
http://dx.doi.org/10.1038/ng.993
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