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More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis

We retrospectively analyzed the presenting features and survival of 194 newly diagnosed patients with multiple myeloma in the People’s Republic of China. Compared with older patients, younger patients had a higher percentage of IgD isotype, lower percentage of International Staging System Stage 3 di...

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Autores principales: Lu, Jin, Lu, Jing, Chen, Wenming, Wang, Jing, Huo, Yuliang, Hou, Jian, Huang, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108500/
https://www.ncbi.nlm.nih.gov/pubmed/27877018
http://dx.doi.org/10.2147/DDDT.S100062
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author Lu, Jin
Lu, Jing
Chen, Wenming
Wang, Jing
Huo, Yuliang
Hou, Jian
Huang, Xiaojun
author_facet Lu, Jin
Lu, Jing
Chen, Wenming
Wang, Jing
Huo, Yuliang
Hou, Jian
Huang, Xiaojun
author_sort Lu, Jin
collection PubMed
description We retrospectively analyzed the presenting features and survival of 194 newly diagnosed patients with multiple myeloma in the People’s Republic of China. Compared with older patients, younger patients had a higher percentage of IgD isotype, lower percentage of International Staging System Stage 3 disease, higher albumin level, and lower frequency of high β2-microglobulin and CD200 expression. There was no difference in sex, Durie–Salmon stage, bone lesion degree, creatinine, lactate dehydrogenase, fluorescence in situ hybridization, and expression of other antigens. Among all 940 newly diagnosed patients with multiple myeloma, those younger than 50 years had better overall survival and progression-free survival than older patients. Of these patients, 457 were treated with a bortezomib-containing regimen, and 450 received conventional therapy. Younger patients treated with bortezomib had better overall survival and progression-free survival than older patients. However, younger patients treated with conventional therapy had the same survival as older patients.
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spelling pubmed-51085002016-11-22 More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis Lu, Jin Lu, Jing Chen, Wenming Wang, Jing Huo, Yuliang Hou, Jian Huang, Xiaojun Drug Des Devel Ther Original Research We retrospectively analyzed the presenting features and survival of 194 newly diagnosed patients with multiple myeloma in the People’s Republic of China. Compared with older patients, younger patients had a higher percentage of IgD isotype, lower percentage of International Staging System Stage 3 disease, higher albumin level, and lower frequency of high β2-microglobulin and CD200 expression. There was no difference in sex, Durie–Salmon stage, bone lesion degree, creatinine, lactate dehydrogenase, fluorescence in situ hybridization, and expression of other antigens. Among all 940 newly diagnosed patients with multiple myeloma, those younger than 50 years had better overall survival and progression-free survival than older patients. Of these patients, 457 were treated with a bortezomib-containing regimen, and 450 received conventional therapy. Younger patients treated with bortezomib had better overall survival and progression-free survival than older patients. However, younger patients treated with conventional therapy had the same survival as older patients. Dove Medical Press 2016-11-08 /pmc/articles/PMC5108500/ /pubmed/27877018 http://dx.doi.org/10.2147/DDDT.S100062 Text en © 2016 Lu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Lu, Jin
Lu, Jing
Chen, Wenming
Wang, Jing
Huo, Yuliang
Hou, Jian
Huang, Xiaojun
More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title_full More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title_fullStr More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title_full_unstemmed More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title_short More frequent IgD and reduced CD200 expression in Chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
title_sort more frequent igd and reduced cd200 expression in chinese patients younger than 50 years old with multiple myeloma: a multicenter analysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108500/
https://www.ncbi.nlm.nih.gov/pubmed/27877018
http://dx.doi.org/10.2147/DDDT.S100062
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