Ret function in muscle stem cells points to tyrosine kinase inhibitor therapy for facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) involves sporadic expression of DUX4, which inhibits myogenesis and is pro-apoptotic. To identify target genes, we over-expressed DUX4 in myoblasts and found that the receptor tyrosine kinase Ret was significantly up-regulated, suggesting a role in FSHD....

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Detalles Bibliográficos
Autores principales: Moyle, Louise A, Blanc, Eric, Jaka, Oihane, Prueller, Johanna, Banerji, Christopher RS, Tedesco, Francesco Saverio, Harridge, Stephen DR, Knight, Robert D, Zammit, Peter S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108591/
https://www.ncbi.nlm.nih.gov/pubmed/27841748
http://dx.doi.org/10.7554/eLife.11405

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