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Protective Effects of Hydrogen Sulfide in the Ageing Kidney

Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-...

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Autores principales: Hou, Cui-Lan, Wang, Ming-Jie, Sun, Chen, Huang, Yong, Jin, Sheng, Mu, Xue-Pan, Chen, Ying, Zhu, Yi-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108860/
https://www.ncbi.nlm.nih.gov/pubmed/27882191
http://dx.doi.org/10.1155/2016/7570489
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author Hou, Cui-Lan
Wang, Ming-Jie
Sun, Chen
Huang, Yong
Jin, Sheng
Mu, Xue-Pan
Chen, Ying
Zhu, Yi-Chun
author_facet Hou, Cui-Lan
Wang, Ming-Jie
Sun, Chen
Huang, Yong
Jin, Sheng
Mu, Xue-Pan
Chen, Ying
Zhu, Yi-Chun
author_sort Hou, Cui-Lan
collection PubMed
description Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing. Chronic H(2)S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition. These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expression upregulation in the ageing kidney after NaHS treatment. Furthermore, the expression of H(2)S-producing enzymes changed with exogenous H(2)S administration and contributed to elevated H(2)S levels in the ageing kidney. Conclusions. Endogenous hydrogen sulfide production in the ageing kidney is insufficient. Exogenous H(2)S can partially rescue ageing-related kidney dysfunction by reducing oxidative stress, decreasing collagen deposition, and enhancing Nrf2 nuclear translocation. Recovery of endogenous hydrogen sulfide production may also contribute to the beneficial effects of NaHS treatment.
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spelling pubmed-51088602016-11-23 Protective Effects of Hydrogen Sulfide in the Ageing Kidney Hou, Cui-Lan Wang, Ming-Jie Sun, Chen Huang, Yong Jin, Sheng Mu, Xue-Pan Chen, Ying Zhu, Yi-Chun Oxid Med Cell Longev Research Article Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing. Chronic H(2)S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition. These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expression upregulation in the ageing kidney after NaHS treatment. Furthermore, the expression of H(2)S-producing enzymes changed with exogenous H(2)S administration and contributed to elevated H(2)S levels in the ageing kidney. Conclusions. Endogenous hydrogen sulfide production in the ageing kidney is insufficient. Exogenous H(2)S can partially rescue ageing-related kidney dysfunction by reducing oxidative stress, decreasing collagen deposition, and enhancing Nrf2 nuclear translocation. Recovery of endogenous hydrogen sulfide production may also contribute to the beneficial effects of NaHS treatment. Hindawi Publishing Corporation 2016 2016-11-01 /pmc/articles/PMC5108860/ /pubmed/27882191 http://dx.doi.org/10.1155/2016/7570489 Text en Copyright © 2016 Cui-Lan Hou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hou, Cui-Lan
Wang, Ming-Jie
Sun, Chen
Huang, Yong
Jin, Sheng
Mu, Xue-Pan
Chen, Ying
Zhu, Yi-Chun
Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title_full Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title_fullStr Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title_full_unstemmed Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title_short Protective Effects of Hydrogen Sulfide in the Ageing Kidney
title_sort protective effects of hydrogen sulfide in the ageing kidney
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108860/
https://www.ncbi.nlm.nih.gov/pubmed/27882191
http://dx.doi.org/10.1155/2016/7570489
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