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Protective Effects of Hydrogen Sulfide in the Ageing Kidney
Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108860/ https://www.ncbi.nlm.nih.gov/pubmed/27882191 http://dx.doi.org/10.1155/2016/7570489 |
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author | Hou, Cui-Lan Wang, Ming-Jie Sun, Chen Huang, Yong Jin, Sheng Mu, Xue-Pan Chen, Ying Zhu, Yi-Chun |
author_facet | Hou, Cui-Lan Wang, Ming-Jie Sun, Chen Huang, Yong Jin, Sheng Mu, Xue-Pan Chen, Ying Zhu, Yi-Chun |
author_sort | Hou, Cui-Lan |
collection | PubMed |
description | Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing. Chronic H(2)S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition. These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expression upregulation in the ageing kidney after NaHS treatment. Furthermore, the expression of H(2)S-producing enzymes changed with exogenous H(2)S administration and contributed to elevated H(2)S levels in the ageing kidney. Conclusions. Endogenous hydrogen sulfide production in the ageing kidney is insufficient. Exogenous H(2)S can partially rescue ageing-related kidney dysfunction by reducing oxidative stress, decreasing collagen deposition, and enhancing Nrf2 nuclear translocation. Recovery of endogenous hydrogen sulfide production may also contribute to the beneficial effects of NaHS treatment. |
format | Online Article Text |
id | pubmed-5108860 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-51088602016-11-23 Protective Effects of Hydrogen Sulfide in the Ageing Kidney Hou, Cui-Lan Wang, Ming-Jie Sun, Chen Huang, Yong Jin, Sheng Mu, Xue-Pan Chen, Ying Zhu, Yi-Chun Oxid Med Cell Longev Research Article Aims. The study aimed to examine whether hydrogen sulfide (H(2)S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function. Results. H(2)S levels in the plasma, urine, and kidney decreased significantly in ageing mice. The expression of two known H(2)S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing. Chronic H(2)S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition. These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expression upregulation in the ageing kidney after NaHS treatment. Furthermore, the expression of H(2)S-producing enzymes changed with exogenous H(2)S administration and contributed to elevated H(2)S levels in the ageing kidney. Conclusions. Endogenous hydrogen sulfide production in the ageing kidney is insufficient. Exogenous H(2)S can partially rescue ageing-related kidney dysfunction by reducing oxidative stress, decreasing collagen deposition, and enhancing Nrf2 nuclear translocation. Recovery of endogenous hydrogen sulfide production may also contribute to the beneficial effects of NaHS treatment. Hindawi Publishing Corporation 2016 2016-11-01 /pmc/articles/PMC5108860/ /pubmed/27882191 http://dx.doi.org/10.1155/2016/7570489 Text en Copyright © 2016 Cui-Lan Hou et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Hou, Cui-Lan Wang, Ming-Jie Sun, Chen Huang, Yong Jin, Sheng Mu, Xue-Pan Chen, Ying Zhu, Yi-Chun Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title | Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title_full | Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title_fullStr | Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title_full_unstemmed | Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title_short | Protective Effects of Hydrogen Sulfide in the Ageing Kidney |
title_sort | protective effects of hydrogen sulfide in the ageing kidney |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108860/ https://www.ncbi.nlm.nih.gov/pubmed/27882191 http://dx.doi.org/10.1155/2016/7570489 |
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