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Mutator Phenotype and DNA Double-Strand Break Repair in BLM Helicase-Deficient Human Cells

Bloom syndrome (BS), an autosomal recessive disorder of the BLM gene, predisposes sufferers to various cancers. To investigate the mutator phenotype and genetic consequences of DNA double-strand breaks (DSBs) in BS cells, we developed BLM helicase-deficient human cells by disrupting the BLM gene. Ce...

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Detalles Bibliográficos
Autores principales:	Suzuki, Tetsuya, Yasui, Manabu, Honma, Masamitsu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108877/ https://www.ncbi.nlm.nih.gov/pubmed/27601585 http://dx.doi.org/10.1128/MCB.00443-16

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