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Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer

A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunos...

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Autores principales: Tsuchikawa, Takahiro, Takeuchi, Shintaro, Nakamura, Toru, Shichinohe, Toshiaki, Hirano, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108980/
https://www.ncbi.nlm.nih.gov/pubmed/27895816
http://dx.doi.org/10.4251/wjgo.v8.i11.786
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author Tsuchikawa, Takahiro
Takeuchi, Shintaro
Nakamura, Toru
Shichinohe, Toshiaki
Hirano, Satoshi
author_facet Tsuchikawa, Takahiro
Takeuchi, Shintaro
Nakamura, Toru
Shichinohe, Toshiaki
Hirano, Satoshi
author_sort Tsuchikawa, Takahiro
collection PubMed
description A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunosuppressive effects. It has recently been shown that certain chemotherapeutic agents could modify tumor microenvironment and host immune responses through several underlying mechanisms such as immunogenic cell death, local T-cell infiltration and also the eradication of immune-suppressing regulatory cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells. With the better understanding of the cell components in the tumor microenvironment and the effect of chemotherapy to improve tumor microenvironment, it has been gradually clear that the chemotherapeutic agents is two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment include infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal chemotherapy. Here we review the recent advances of chemotherapy to improve tumor microenvironment of pancreatic cancer, introducing the unique feature of tumor microenvironment of pancreatic cancer, interaction between anti-cancer reagents and these constituting cells and future prospects.
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spelling pubmed-51089802016-11-28 Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer Tsuchikawa, Takahiro Takeuchi, Shintaro Nakamura, Toru Shichinohe, Toshiaki Hirano, Satoshi World J Gastrointest Oncol Minireviews A perioperative multimodal strategy including combination chemotherapy and radiotherapy, in addition to surgical resection, has been acknowledged to improve patient prognosis. However chemotherapy has not been actively applied as an immunomodulating modality because of concerns about various immunosuppressive effects. It has recently been shown that certain chemotherapeutic agents could modify tumor microenvironment and host immune responses through several underlying mechanisms such as immunogenic cell death, local T-cell infiltration and also the eradication of immune-suppressing regulatory cells such as regulatory T cells (Tregs) and myeloid-derived suppressor cells. With the better understanding of the cell components in the tumor microenvironment and the effect of chemotherapy to improve tumor microenvironment, it has been gradually clear that the chemotherapeutic agents is two-edged sword to have both immune promoting and suppressing effects. The cellular components of the tumor microenvironment include infiltrating T lymphocytes, dendritic cells, regulatory T cells, tumor associated macrophages, myeloid derived suppressor cells and cancer associated fibroblasts. Based on the better understanding of tumor microenvironment following chemotherapy, the treatment protocol could be modified as personalized medicine and the prognosis of pancreas cancer would be more improved utilizing multimodal chemotherapy. Here we review the recent advances of chemotherapy to improve tumor microenvironment of pancreatic cancer, introducing the unique feature of tumor microenvironment of pancreatic cancer, interaction between anti-cancer reagents and these constituting cells and future prospects. Baishideng Publishing Group Inc 2016-11-15 2016-11-15 /pmc/articles/PMC5108980/ /pubmed/27895816 http://dx.doi.org/10.4251/wjgo.v8.i11.786 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Minireviews
Tsuchikawa, Takahiro
Takeuchi, Shintaro
Nakamura, Toru
Shichinohe, Toshiaki
Hirano, Satoshi
Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title_full Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title_fullStr Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title_full_unstemmed Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title_short Clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
title_sort clinical impact of chemotherapy to improve tumor microenvironment of pancreatic cancer
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108980/
https://www.ncbi.nlm.nih.gov/pubmed/27895816
http://dx.doi.org/10.4251/wjgo.v8.i11.786
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