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Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak
The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Leibniz Research Centre for Working Environment and Human Factors
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109022/ https://www.ncbi.nlm.nih.gov/pubmed/27857669 |
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author | Su, Jian-Yu Li, Qing-Chan Zhu, Liang |
author_facet | Su, Jian-Yu Li, Qing-Chan Zhu, Liang |
author_sort | Su, Jian-Yu |
collection | PubMed |
description | The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 mg/kg, the clinical anti-inflammatory indomethacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin or serotonin, most notably at the highest test dose of 20 mg/kg. In the cotton pellet-induced granuloma model, the compound showed dose-dependent anti-inflammatory activity, with the highest effect at 20 mg/kg. In all three assays, the flavone glucoside compound was more active at 20 mg/kg than indomethacin at 10 mg/kg. |
format | Online Article Text |
id | pubmed-5109022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Leibniz Research Centre for Working Environment and Human Factors |
record_format | MEDLINE/PubMed |
spelling | pubmed-51090222016-11-17 Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak Su, Jian-Yu Li, Qing-Chan Zhu, Liang EXCLI J Original Article The anti-inflammatory effect of selagin-7-O-(6″-O-Acetyl-)-β-D-glucoside, isolated from the medicinal herb Cancrinia discoidea (Ledeb.) Poljak, was evaluated for its anti-inflammatory activity in the carrageenin- and serotonin-induced rat paw oedema models of acute inflammation and the cotton pellet-induced granuloma rat model of chronic inflammation. Flavone glycoside at doses of 5, 10, or 20 mg/kg, the clinical anti-inflammatory indomethacin at 10 mg/kg, or vehicle were administered orally before injection of the pro-inflammatory compound. The test compound showed significant anti-inflammatory activity against paw edema induced by carrageenin or serotonin, most notably at the highest test dose of 20 mg/kg. In the cotton pellet-induced granuloma model, the compound showed dose-dependent anti-inflammatory activity, with the highest effect at 20 mg/kg. In all three assays, the flavone glucoside compound was more active at 20 mg/kg than indomethacin at 10 mg/kg. Leibniz Research Centre for Working Environment and Human Factors 2011-08-16 /pmc/articles/PMC5109022/ /pubmed/27857669 Text en Copyright © 2011 Su et al. http://www.excli.de/documents/assignment_of_rights.pdf This is an Open Access article distributed under the following Assignment of Rights http://www.excli.de/documents/assignment_of_rights.pdf. You are free to copy, distribute and transmit the work, provided the original author and source are credited. |
spellingShingle | Original Article Su, Jian-Yu Li, Qing-Chan Zhu, Liang Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title | Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title_full | Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title_fullStr | Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title_full_unstemmed | Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title_short | Evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from Cancrinia discoidea (Ledeb.) Poljak |
title_sort | evaluation of the in vivo anti-inflammatory activity of a flavone glycoside from cancrinia discoidea (ledeb.) poljak |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109022/ https://www.ncbi.nlm.nih.gov/pubmed/27857669 |
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