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MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3
An increase in hepatic triglyceride (TG) contents usually results in non-alcoholic fatty liver disease (NAFLD) and related metabolic diseases. However, the mechanisms underlying perturbations of hepatic TG homeostasis remain largely unknown. Here, we showed that MicroRNA-124 was up-regulated in the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109039/ https://www.ncbi.nlm.nih.gov/pubmed/27845424 http://dx.doi.org/10.1038/srep37170 |
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author | Liu, Xing Zhao, Jiejie Liu, Qi Xiong, Xuelian Zhang, Zhijian Jiao, Yang Li, Xiaoying Liu, Bin Li, Yao Lu, Yan |
author_facet | Liu, Xing Zhao, Jiejie Liu, Qi Xiong, Xuelian Zhang, Zhijian Jiao, Yang Li, Xiaoying Liu, Bin Li, Yao Lu, Yan |
author_sort | Liu, Xing |
collection | PubMed |
description | An increase in hepatic triglyceride (TG) contents usually results in non-alcoholic fatty liver disease (NAFLD) and related metabolic diseases. However, the mechanisms underlying perturbations of hepatic TG homeostasis remain largely unknown. Here, we showed that MicroRNA-124 was up-regulated in the livers of C57BL/6 mice fed a short-term high-fat-diet (HFD). Adenoviral overexpression of miR-124 in C57BL/6 mice led to accumulation of excessive triglycerides and up-regulation of lipogenic genes in the liver. We further identified tribbles homolog 3 (TRB3) as a direct target of miR-124. AKT signaling, which is negatively regulated by TRB3, was enhanced by miR-124 overexpression. Moreover, restoration of TRB3 expression markedly abolished the effect of miR-124 on hepatic TG metabolism. Therefore, our findings revealed that miR-124 played a role in mediating high-fat-diet induced TG accumulation in the liver. |
format | Online Article Text |
id | pubmed-5109039 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-51090392016-11-25 MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 Liu, Xing Zhao, Jiejie Liu, Qi Xiong, Xuelian Zhang, Zhijian Jiao, Yang Li, Xiaoying Liu, Bin Li, Yao Lu, Yan Sci Rep Article An increase in hepatic triglyceride (TG) contents usually results in non-alcoholic fatty liver disease (NAFLD) and related metabolic diseases. However, the mechanisms underlying perturbations of hepatic TG homeostasis remain largely unknown. Here, we showed that MicroRNA-124 was up-regulated in the livers of C57BL/6 mice fed a short-term high-fat-diet (HFD). Adenoviral overexpression of miR-124 in C57BL/6 mice led to accumulation of excessive triglycerides and up-regulation of lipogenic genes in the liver. We further identified tribbles homolog 3 (TRB3) as a direct target of miR-124. AKT signaling, which is negatively regulated by TRB3, was enhanced by miR-124 overexpression. Moreover, restoration of TRB3 expression markedly abolished the effect of miR-124 on hepatic TG metabolism. Therefore, our findings revealed that miR-124 played a role in mediating high-fat-diet induced TG accumulation in the liver. Nature Publishing Group 2016-11-15 /pmc/articles/PMC5109039/ /pubmed/27845424 http://dx.doi.org/10.1038/srep37170 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Liu, Xing Zhao, Jiejie Liu, Qi Xiong, Xuelian Zhang, Zhijian Jiao, Yang Li, Xiaoying Liu, Bin Li, Yao Lu, Yan MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title_full | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title_fullStr | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title_full_unstemmed | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title_short | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
title_sort | microrna-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109039/ https://www.ncbi.nlm.nih.gov/pubmed/27845424 http://dx.doi.org/10.1038/srep37170 |
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