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Ligand-mediated changes in conformational dynamics of NpmA: implications for ribosomal interactions

Aminoglycosides are broad-spectrum antibiotics that bind to the 30S ribosomal subunit (30S) of bacteria and disrupt protein translation. NpmA, a structurally well-characterized methyltransferase identified in an E. coli clinical isolate, catalyzes methylation of 30S at A1408 of the 16S rRNA and conf...

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Detalles Bibliográficos
Autores principales:	Husain, Nilofer, Tulsian, Nikhil Kumar, Chien, Wang Loo, Suresh, Sushant, Anand, Ganesh Srinivasan, Sivaraman, J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109232/ https://www.ncbi.nlm.nih.gov/pubmed/27845431 http://dx.doi.org/10.1038/srep37061

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