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Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study

Anaemia during pregnancy is most commonly observed and highly prevalent in South-East Asia. Various effective programmes have been laid down for its management, mainly daily supplementation of iron folic acid (IFA) tablets. Following the same, standard obstetrical practice has included the IFA suppl...

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Autores principales: Shankar, Hari, Kumar, Neeta, Sandhir, Rajat, Mittal, Suneeta, Kurra, Santosh, Dhaliwal, Lakhbir, Kaur, Gurjit, Chandhiok, Nomita, Dhillon, B.S., Rao, D.N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109292/
https://www.ncbi.nlm.nih.gov/pubmed/27872568
http://dx.doi.org/10.1016/j.sjbs.2015.09.007
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author Shankar, Hari
Kumar, Neeta
Sandhir, Rajat
Mittal, Suneeta
Kurra, Santosh
Dhaliwal, Lakhbir
Kaur, Gurjit
Chandhiok, Nomita
Dhillon, B.S.
Rao, D.N.
author_facet Shankar, Hari
Kumar, Neeta
Sandhir, Rajat
Mittal, Suneeta
Kurra, Santosh
Dhaliwal, Lakhbir
Kaur, Gurjit
Chandhiok, Nomita
Dhillon, B.S.
Rao, D.N.
author_sort Shankar, Hari
collection PubMed
description Anaemia during pregnancy is most commonly observed and highly prevalent in South-East Asia. Various effective programmes have been laid down for its management, mainly daily supplementation of iron folic acid (IFA) tablets. Following the same, standard obstetrical practice has included the IFA supplementation without requiring the determination of iron deficiency. In this study, a total of 120 primigravida (N = 60; non-anaemic (Hb > 11 g/dl) and N = 60 anaemic (Hb = 8–11 g/dl)) were selected among those attending the Antenatal Clinic in Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. They were supplemented with daily and weekly IFA tablets till 6 weeks postpartum. Corresponding changes in haemoglobin level on advance of pregnancy, side effects and compliance associated with daily and weekly IFA supplementation and its associations with iron status markers were studied. The inflammatory markers were also estimated. The statistical significance level (p < 0.05) between the groups were assessed by applying unpaired t-test using SPSS (version 16.0). The obtained results publicized the salutary role of daily IFA supplementation in improving the haemoglobin level and iron status markers in anaemic pregnant women though the levels could not reach up to the non-anaemic haemoglobin levels. However, weekly IFA supplementation seems to be a better approach in non-anaemic pregnant women where almost comparable results were obtained in terms of haematological parameters, gestation length and birth weight. CONCLUSION: Weekly IFA supplementation found to be as effective as daily supplementation in iron sufficient non-anaemic pregnant women whereas anaemic pregnant women should be prescribed daily IFA supplementation irrespective of iron replete/deplete state.
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spelling pubmed-51092922016-11-21 Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study Shankar, Hari Kumar, Neeta Sandhir, Rajat Mittal, Suneeta Kurra, Santosh Dhaliwal, Lakhbir Kaur, Gurjit Chandhiok, Nomita Dhillon, B.S. Rao, D.N. Saudi J Biol Sci Original Article Anaemia during pregnancy is most commonly observed and highly prevalent in South-East Asia. Various effective programmes have been laid down for its management, mainly daily supplementation of iron folic acid (IFA) tablets. Following the same, standard obstetrical practice has included the IFA supplementation without requiring the determination of iron deficiency. In this study, a total of 120 primigravida (N = 60; non-anaemic (Hb > 11 g/dl) and N = 60 anaemic (Hb = 8–11 g/dl)) were selected among those attending the Antenatal Clinic in Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. They were supplemented with daily and weekly IFA tablets till 6 weeks postpartum. Corresponding changes in haemoglobin level on advance of pregnancy, side effects and compliance associated with daily and weekly IFA supplementation and its associations with iron status markers were studied. The inflammatory markers were also estimated. The statistical significance level (p < 0.05) between the groups were assessed by applying unpaired t-test using SPSS (version 16.0). The obtained results publicized the salutary role of daily IFA supplementation in improving the haemoglobin level and iron status markers in anaemic pregnant women though the levels could not reach up to the non-anaemic haemoglobin levels. However, weekly IFA supplementation seems to be a better approach in non-anaemic pregnant women where almost comparable results were obtained in terms of haematological parameters, gestation length and birth weight. CONCLUSION: Weekly IFA supplementation found to be as effective as daily supplementation in iron sufficient non-anaemic pregnant women whereas anaemic pregnant women should be prescribed daily IFA supplementation irrespective of iron replete/deplete state. Elsevier 2016-11 2015-09-05 /pmc/articles/PMC5109292/ /pubmed/27872568 http://dx.doi.org/10.1016/j.sjbs.2015.09.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Shankar, Hari
Kumar, Neeta
Sandhir, Rajat
Mittal, Suneeta
Kurra, Santosh
Dhaliwal, Lakhbir
Kaur, Gurjit
Chandhiok, Nomita
Dhillon, B.S.
Rao, D.N.
Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title_full Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title_fullStr Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title_full_unstemmed Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title_short Weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: A randomized controlled study
title_sort weekly iron folic acid supplementation plays differential role in maintaining iron markers level in non-anaemic and anaemic primigravida: a randomized controlled study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109292/
https://www.ncbi.nlm.nih.gov/pubmed/27872568
http://dx.doi.org/10.1016/j.sjbs.2015.09.007
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