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Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis

[Image: see text] Although serine proteases are important mediators of Mycobacterium tuberculosis (Mtb) virulence, there are currently no tools to selectively block or visualize members of this family of enzymes. Selective reporter substrates or activity-based probes (ABPs) could provide a means to...

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Detalles Bibliográficos
Autores principales:	Lentz, Christian S., Ordonez, Alvaro A., Kasperkiewicz, Paulina, La Greca, Florencia, O’Donoghue, Anthony J., Schulze, Christopher J., Powers, James C., Craik, Charles S., Drag, Marcin, Jain, Sanjay K., Bogyo, Matthew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109297/ https://www.ncbi.nlm.nih.gov/pubmed/27739665 http://dx.doi.org/10.1021/acsinfecdis.6b00092

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