The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice

BACKGROUND: Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin...

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Autores principales: Mahboubi, Mohaddese, Feizabadi, Mohammad Mehdi, Khamechian, Tahereh, Kazempour, Nastaran, Razavi Zadeh, Mohsen, Sasani, Farhang, Bekhradi, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Society for Plastic Surgeons 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109387/
https://www.ncbi.nlm.nih.gov/pubmed/27853689
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author Mahboubi, Mohaddese
Feizabadi, Mohammad Mehdi
Khamechian, Tahereh
Kazempour, Nastaran
Razavi Zadeh, Mohsen
Sasani, Farhang
Bekhradi, Mohsen
author_facet Mahboubi, Mohaddese
Feizabadi, Mohammad Mehdi
Khamechian, Tahereh
Kazempour, Nastaran
Razavi Zadeh, Mohsen
Sasani, Farhang
Bekhradi, Mohsen
author_sort Mahboubi, Mohaddese
collection PubMed
description BACKGROUND: Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection. METHODS: The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model. RESULTS: The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureus from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction. CONCLUSION: This natural new formulation with O. decumbens and P. graveolens essential oils could be recommended as a new candidate for wound healing.
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spelling pubmed-51093872016-11-16 The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice Mahboubi, Mohaddese Feizabadi, Mohammad Mehdi Khamechian, Tahereh Kazempour, Nastaran Razavi Zadeh, Mohsen Sasani, Farhang Bekhradi, Mohsen World J Plast Surg Original Article BACKGROUND: Staphylococcus aureus is one of the most causative organisms in the skin wound infections. Development of resistant S. aureus to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection. METHODS: The efficacy of herbal formulation containing Oliveria decumbens and Pelargonium graveolens essential oils was evaluated in comparison to mupirocin against Methicillin Resistant S. aureus (MRSA) related skin wound infection in mice animal model. RESULTS: The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of S. aureus from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction. CONCLUSION: This natural new formulation with O. decumbens and P. graveolens essential oils could be recommended as a new candidate for wound healing. Iranian Society for Plastic Surgeons 2016-09 /pmc/articles/PMC5109387/ /pubmed/27853689 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mahboubi, Mohaddese
Feizabadi, Mohammad Mehdi
Khamechian, Tahereh
Kazempour, Nastaran
Razavi Zadeh, Mohsen
Sasani, Farhang
Bekhradi, Mohsen
The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title_full The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title_fullStr The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title_full_unstemmed The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title_short The Effect of Oliveria Decumbens and Pelargonium Graveolens on Healing of Infected Skin Wounds in Mice
title_sort effect of oliveria decumbens and pelargonium graveolens on healing of infected skin wounds in mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109387/
https://www.ncbi.nlm.nih.gov/pubmed/27853689
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