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Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions
K-Ras is the most frequently mutated oncogene in human cancers, but there are still no drugs that directly target it in the clinic. Recent studies utilizing dynamics information show promising results for selectively targeting mutant K-Ras. However, despite extensive characterization, the mechanisms...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109477/ https://www.ncbi.nlm.nih.gov/pubmed/27845397 http://dx.doi.org/10.1038/srep37012 |