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Mutation tendency of mutator Plasmodium berghei with proofreading-deficient DNA polymerase δ

In this study, we investigated the mutation tendency of a mutator rodent malaria parasite, Plasmodium berghei, with proofreading-deficient DNA polymerase δ. Wild-type and mutator parasites were maintained in mice for over 24 weeks, and the genome-wide accumulated mutations were determined by high-th...

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Detalles Bibliográficos
Autores principales:	Honma, Hajime, Niikura, Mamoru, Kobayashi, Fumie, Horii, Toshihiro, Mita, Toshihiro, Endo, Hiroyoshi, Hirai, Makoto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109483/ https://www.ncbi.nlm.nih.gov/pubmed/27845384 http://dx.doi.org/10.1038/srep36971

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