Sensing of HSV-1 by the cGAS–STING pathway in microglia orchestrates antiviral defence in the CNS

Herpes simplex encephalitis (HSE) is the most common form of acute viral encephalitis in industrialized countries. Type I interferon (IFN) is important for control of herpes simplex virus (HSV-1) in the central nervous system (CNS). Here we show that microglia are the main source of HSV-induced type...

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Detalles Bibliográficos
Autores principales: Reinert, Line S., Lopušná, Katarína, Winther, Henriette, Sun, Chenglong, Thomsen, Martin K., Nandakumar, Ramya, Mogensen, Trine H., Meyer, Morten, Vægter, Christian, Nyengaard, Jens R., Fitzgerald, Katherine A., Paludan, Søren R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109551/
https://www.ncbi.nlm.nih.gov/pubmed/27830700
http://dx.doi.org/10.1038/ncomms13348

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