Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production

The patient was a 61-year-old woman who had a well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation of the tongue and moon face developed, leading to the diagnosis of ectopic adren...

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Autores principales: Tadokoro, Rie, Sato, Shotaro, Otsuka, Fumiko, Ueno, Makoto, Ohkawa, Shinichi, Katakami, Hideki, Taniyama, Matsuo, Nagasaka, Shoichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109566/
https://www.ncbi.nlm.nih.gov/pubmed/27746436
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author Tadokoro, Rie
Sato, Shotaro
Otsuka, Fumiko
Ueno, Makoto
Ohkawa, Shinichi
Katakami, Hideki
Taniyama, Matsuo
Nagasaka, Shoichiro
author_facet Tadokoro, Rie
Sato, Shotaro
Otsuka, Fumiko
Ueno, Makoto
Ohkawa, Shinichi
Katakami, Hideki
Taniyama, Matsuo
Nagasaka, Shoichiro
author_sort Tadokoro, Rie
collection PubMed
description The patient was a 61-year-old woman who had a well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation of the tongue and moon face developed, leading to the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome. An abnormal secretion of growth hormone (GH) was identified, and the plasma growth hormone-releasing hormone (GHRH) level was elevated. A tumor biopsy specimen positively immunostained for ACTH and GHRH. Ectopic hormone secretion seems to have evolved along with the progression of the PNET.
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spelling pubmed-51095662016-11-17 Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production Tadokoro, Rie Sato, Shotaro Otsuka, Fumiko Ueno, Makoto Ohkawa, Shinichi Katakami, Hideki Taniyama, Matsuo Nagasaka, Shoichiro Intern Med Case Report The patient was a 61-year-old woman who had a well-differentiated pancreatic neuroendocrine tumor (PNET) with lymph node metastasis. After 15 months of octreotide treatment, glucose control deteriorated and pigmentation of the tongue and moon face developed, leading to the diagnosis of ectopic adrenocorticotropic hormone (ACTH) syndrome. An abnormal secretion of growth hormone (GH) was identified, and the plasma growth hormone-releasing hormone (GHRH) level was elevated. A tumor biopsy specimen positively immunostained for ACTH and GHRH. Ectopic hormone secretion seems to have evolved along with the progression of the PNET. The Japanese Society of Internal Medicine 2016-10-15 /pmc/articles/PMC5109566/ /pubmed/27746436 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Tadokoro, Rie
Sato, Shotaro
Otsuka, Fumiko
Ueno, Makoto
Ohkawa, Shinichi
Katakami, Hideki
Taniyama, Matsuo
Nagasaka, Shoichiro
Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title_full Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title_fullStr Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title_full_unstemmed Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title_short Metastatic Pancreatic Neuroendocrine Tumor that Progressed to Ectopic Adrenocorticotropic Hormone (ACTH) Syndrome with Growth Hormone-releasing Hormone (GHRH) Production
title_sort metastatic pancreatic neuroendocrine tumor that progressed to ectopic adrenocorticotropic hormone (acth) syndrome with growth hormone-releasing hormone (ghrh) production
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109566/
https://www.ncbi.nlm.nih.gov/pubmed/27746436
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