Hyperglycaemia inhibits REG3A expression to exacerbate TLR3-mediated skin inflammation in diabetes

Dysregulated inflammatory responses are known to impair wound healing in diabetes, but the underlying mechanisms are poorly understood. Here we show that the antimicrobial protein REG3A controls TLR3-mediated inflammation after skin injury. This control is mediated by REG3A-induced SHP-1 protein, an...

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Detalles Bibliográficos
Autores principales: Wu, Yelin, Quan, Yanchun, Liu, Yuanqi, Liu, Keiwei, Li, Hongquan, Jiang, Ziwei, Zhang, Tian, Lei, Hu, Radek, Katherine A., Li, Dongqing, Wang, Zhenhua, Lu, Jilong, Wang, Wang, Ji, Shizhao, Xia, Zhaofan, Lai, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109591/
https://www.ncbi.nlm.nih.gov/pubmed/27830702
http://dx.doi.org/10.1038/ncomms13393

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