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Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid

Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer’s disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal flui...

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Autores principales: Roberts, Blaine R., Doecke, James D., Rembach, Alan, Yévenes, L. Fernanda, Fowler, Christopher J., McLean, Catriona A., Lind, Monica, Volitakis, Irene, Masters, Colin L., Bush, Ashley I., Hare, Dominic J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109650/
https://www.ncbi.nlm.nih.gov/pubmed/27842602
http://dx.doi.org/10.1186/s40478-016-0390-8
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author Roberts, Blaine R.
Doecke, James D.
Rembach, Alan
Yévenes, L. Fernanda
Fowler, Christopher J.
McLean, Catriona A.
Lind, Monica
Volitakis, Irene
Masters, Colin L.
Bush, Ashley I.
Hare, Dominic J.
author_facet Roberts, Blaine R.
Doecke, James D.
Rembach, Alan
Yévenes, L. Fernanda
Fowler, Christopher J.
McLean, Catriona A.
Lind, Monica
Volitakis, Irene
Masters, Colin L.
Bush, Ashley I.
Hare, Dominic J.
author_sort Roberts, Blaine R.
collection PubMed
description Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer’s disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal fluid from Alzheimer’s disease and healthy control subjects to investigate the diagnostic potential of these two metal ions. We found that both potassium and rubidium levels were significantly decreased across all intracellular compartments in the Alzheimer’s disease brain. Serum from over 1000 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), showed minor changes according to disease state. Potassium and rubidium levels in erythrocytes and cerebrospinal fluid were not significantly different according to disease state, and rubidium was slightly decreased in Alzheimer’s disease patients compared to healthy controls. Our data provides evidence that contrasts the hypothesized disruption of the blood-brain barrier in Alzheimer’s disease, with the systemic decrease in cortical potassium and rubidium levels suggesting influx of ions from the blood is minimal and that the observed changes are more likely indicative of an internal energy crisis within the brain. These findings may be the basis for potential diagnostic imaging studies using radioactive potassium and rubidium tracers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40478-016-0390-8) contains supplementary material, which is available to authorized users.
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spelling pubmed-51096502016-11-28 Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid Roberts, Blaine R. Doecke, James D. Rembach, Alan Yévenes, L. Fernanda Fowler, Christopher J. McLean, Catriona A. Lind, Monica Volitakis, Irene Masters, Colin L. Bush, Ashley I. Hare, Dominic J. Acta Neuropathol Commun Research Loss of intracellular compartmentalization of potassium is a biochemical feature of Alzheimer’s disease indicating a loss of membrane integrity and mitochondrial dysfunction. We examined potassium and rubidium (a biological proxy for potassium) in brain tissue, blood fractions and cerebrospinal fluid from Alzheimer’s disease and healthy control subjects to investigate the diagnostic potential of these two metal ions. We found that both potassium and rubidium levels were significantly decreased across all intracellular compartments in the Alzheimer’s disease brain. Serum from over 1000 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL), showed minor changes according to disease state. Potassium and rubidium levels in erythrocytes and cerebrospinal fluid were not significantly different according to disease state, and rubidium was slightly decreased in Alzheimer’s disease patients compared to healthy controls. Our data provides evidence that contrasts the hypothesized disruption of the blood-brain barrier in Alzheimer’s disease, with the systemic decrease in cortical potassium and rubidium levels suggesting influx of ions from the blood is minimal and that the observed changes are more likely indicative of an internal energy crisis within the brain. These findings may be the basis for potential diagnostic imaging studies using radioactive potassium and rubidium tracers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s40478-016-0390-8) contains supplementary material, which is available to authorized users. BioMed Central 2016-11-14 /pmc/articles/PMC5109650/ /pubmed/27842602 http://dx.doi.org/10.1186/s40478-016-0390-8 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Roberts, Blaine R.
Doecke, James D.
Rembach, Alan
Yévenes, L. Fernanda
Fowler, Christopher J.
McLean, Catriona A.
Lind, Monica
Volitakis, Irene
Masters, Colin L.
Bush, Ashley I.
Hare, Dominic J.
Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title_full Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title_fullStr Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title_full_unstemmed Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title_short Rubidium and potassium levels are altered in Alzheimer’s disease brain and blood but not in cerebrospinal fluid
title_sort rubidium and potassium levels are altered in alzheimer’s disease brain and blood but not in cerebrospinal fluid
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109650/
https://www.ncbi.nlm.nih.gov/pubmed/27842602
http://dx.doi.org/10.1186/s40478-016-0390-8
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