Novel extracellular and nuclear caspase-1 and inflammasomes propagate inflammation and regulate gene expression: a comprehensive database mining study

BACKGROUND: Caspase-1 is present in the cytosol as an inactive zymogen and requires the protein complexes named “inflammasomes” for proteolytic activation. However, it remains unclear whether the proteolytic activity of caspase-1 is confined only to the cytosol where inflammasomes are assembled to c...

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Detalles Bibliográficos
Autores principales: Wang, Luqiao, Fu, Hangfei, Nanayakkara, Gayani, Li, Yafeng, Shao, Ying, Johnson, Candice, Cheng, Jiali, Yang, William Y., Yang, Fan, Lavallee, Muriel, Xu, Yanjie, Cheng, Xiaoshu, Xi, Hang, Yi, Jonathan, Yu, Jun, Choi, Eric T., Wang, Hong, Yang, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109738/
https://www.ncbi.nlm.nih.gov/pubmed/27842563
http://dx.doi.org/10.1186/s13045-016-0351-5

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