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Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia
Deficits in the adaptive, flexible control of behavior contribute to the clinical manifestations of schizophrenia. We used functional MRI and an antisaccade paradigm to examine the neural correlates of cognitive control deficits and their relations to symptom severity. Thirty-three chronic medicated...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109850/ https://www.ncbi.nlm.nih.gov/pubmed/27872811 http://dx.doi.org/10.1016/j.nicl.2016.10.020 |
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author | Baran, Bengi Karahanoğlu, F. Işık Agam, Yigal Mantonakis, Leonidas Manoach, Dara S. |
author_facet | Baran, Bengi Karahanoğlu, F. Işık Agam, Yigal Mantonakis, Leonidas Manoach, Dara S. |
author_sort | Baran, Bengi |
collection | PubMed |
description | Deficits in the adaptive, flexible control of behavior contribute to the clinical manifestations of schizophrenia. We used functional MRI and an antisaccade paradigm to examine the neural correlates of cognitive control deficits and their relations to symptom severity. Thirty-three chronic medicated outpatients with schizophrenia and 31 healthy controls performed an antisaccade paradigm. We examined differences in recruitment of the cognitive control network and task performance for Hard (high control) versus Easy (low control) antisaccade trials within and between groups. We focused on the key regions involved in ‘top-down’ control of ocular motor structures – dorsal anterior cingulate cortex, dorsolateral and ventrolateral prefrontal cortex. In patients, we examined whether difficulty implementing cognitive control correlated with symptom severity. Patients made more errors overall, and had shorter saccadic latencies than controls on correct Hard vs. Easy trials. Unlike controls, patients failed to increase activation in the cognitive control network for Hard vs. Easy trials. Reduced activation for Hard vs. Easy trials predicted higher error rates in both groups and increased symptom severity in schizophrenia. These findings suggest that patients with schizophrenia are impaired in mobilizing cognitive control when presented with challenges and that this contributes to deficits suppressing prepotent but contextually inappropriate responses, to behavior that is stimulus-bound and error-prone rather than flexibly guided by context, and to symptom expression. Therapies aimed at increasing cognitive control may improve both cognitive flexibility and reduce the impact of symptoms. |
format | Online Article Text |
id | pubmed-5109850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-51098502016-11-21 Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia Baran, Bengi Karahanoğlu, F. Işık Agam, Yigal Mantonakis, Leonidas Manoach, Dara S. Neuroimage Clin Regular Article Deficits in the adaptive, flexible control of behavior contribute to the clinical manifestations of schizophrenia. We used functional MRI and an antisaccade paradigm to examine the neural correlates of cognitive control deficits and their relations to symptom severity. Thirty-three chronic medicated outpatients with schizophrenia and 31 healthy controls performed an antisaccade paradigm. We examined differences in recruitment of the cognitive control network and task performance for Hard (high control) versus Easy (low control) antisaccade trials within and between groups. We focused on the key regions involved in ‘top-down’ control of ocular motor structures – dorsal anterior cingulate cortex, dorsolateral and ventrolateral prefrontal cortex. In patients, we examined whether difficulty implementing cognitive control correlated with symptom severity. Patients made more errors overall, and had shorter saccadic latencies than controls on correct Hard vs. Easy trials. Unlike controls, patients failed to increase activation in the cognitive control network for Hard vs. Easy trials. Reduced activation for Hard vs. Easy trials predicted higher error rates in both groups and increased symptom severity in schizophrenia. These findings suggest that patients with schizophrenia are impaired in mobilizing cognitive control when presented with challenges and that this contributes to deficits suppressing prepotent but contextually inappropriate responses, to behavior that is stimulus-bound and error-prone rather than flexibly guided by context, and to symptom expression. Therapies aimed at increasing cognitive control may improve both cognitive flexibility and reduce the impact of symptoms. Elsevier 2016-10-28 /pmc/articles/PMC5109850/ /pubmed/27872811 http://dx.doi.org/10.1016/j.nicl.2016.10.020 Text en © 2016 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Baran, Bengi Karahanoğlu, F. Işık Agam, Yigal Mantonakis, Leonidas Manoach, Dara S. Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title | Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title_full | Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title_fullStr | Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title_full_unstemmed | Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title_short | Failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
title_sort | failure to mobilize cognitive control for challenging tasks correlates with symptom severity in schizophrenia |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109850/ https://www.ncbi.nlm.nih.gov/pubmed/27872811 http://dx.doi.org/10.1016/j.nicl.2016.10.020 |
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