Cargando…

Enhancing succinic acid biosynthesis in Escherichia coli by engineering its global transcription factor, catabolite repressor/activator (Cra)

This study was initiated to improve E. coli succinate production by engineering the E. coli global transcription factor, Cra (catabolite repressor/activator). Random mutagenesis libraries were generated through error-prone PCR of cra. After re-screening and mutation site integration, the best mutant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Li-Wen, Xia, Shi-Tao, Wei, Li-Na, Li, Hong-Mei, Yuan, Zhan-Peng, Tang, Ya-Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5109907/ https://www.ncbi.nlm.nih.gov/pubmed/27811970 http://dx.doi.org/10.1038/srep36526

Ejemplares similares

Succinate production positively correlates with the affinity of the global transcription factor Cra for its effector FBP in Escherichia coli
por: Wei, Li-Na, et al.
Publicado: (2016)

Collaborative regulation of CO(2) transport and fixation during succinate production in Escherichia coli
por: Zhu, Li-Wen, et al.
Publicado: (2015)

Virulence Meets Metabolism: Cra and KdpE Gene Regulation in Enterohemorrhagic Escherichia coli
por: Njoroge, Jacqueline W., et al.
Publicado: (2012)

Catabolite and Oxygen Regulation of Enterohemorrhagic Escherichia coli Virulence
por: Carlson-Banning, Kimberly M., et al.
Publicado: (2016)

Uropathogenic Escherichia coli wield enterobactin-derived catabolites as siderophores
por: Zou, Zongsen, et al.
Publicado: (2023)

Targeted optimization of central carbon metabolism for engineering succinate production in Escherichia coli
por: Zhao, Ying, et al.
Publicado: (2016)

Molecular basis for cell-wall recycling regulation by transcriptional repressor MurR in Escherichia coli
por: Zhang, Ya, et al.
Publicado: (2022)

Metabolic Engineering of Escherichia coli for Hyperoside Biosynthesis
por: Li, Guosi, et al.
Publicado: (2022)

Engineering Escherichia coli for succinate production from hemicellulose via consolidated bioprocessing
por: Zheng, Zongbao, et al.
Publicado: (2012)

Systematic engineering of pentose phosphate pathway improves Escherichia coli succinate production
por: Tan, Zaigao, et al.
Publicado: (2016)

Engineered polyketide biosynthesis and biocatalysis in Escherichia coli
por: Gao, Xue, et al.
Publicado: (2010)

In vitro transcription accurately predicts lac repressor phenotype in vivo in Escherichia coli
por: Sochor, Matthew Almond
Publicado: (2014)

Engineering of global transcription factor FruR to redirect the carbon flow in Escherichia coli for enhancing l-phenylalanine biosynthesis
por: Chen, Minliang, et al.
Publicado: (2022)

Engineering an electroactive Escherichia coli for the microbial electrosynthesis of succinate from glucose and CO(2)
por: Wu, Zaiqiang, et al.
Publicado: (2019)

The Role of Protein-Ligand Contacts in Allosteric Regulation of the Escherichia coli Catabolite Activator Protein
por: Townsend, Philip D., et al.
Publicado: (2015)

Systems assessment of transcriptional regulation on central carbon metabolism by Cra and CRP
por: Kim, Donghyuk, et al.
Publicado: (2018)

Biosynthesis of L‐5‐methyltetrahydrofolate by genetically engineered Escherichia coli
por: Wang, Yubo, et al.
Publicado: (2022)

Metabolic engineering of Escherichia coli for the biosynthesis of alpha-pinene
por: Yang, Jianming, et al.
Publicado: (2013)

Metabolic Engineering for Resveratrol Derivative Biosynthesis in Escherichia coli
por: Jeong, Yu Jeong, et al.
Publicado: (2015)

Metabolic engineering of Escherichia coli for enhanced arginine biosynthesis
por: Ginesy, Mireille, et al.
Publicado: (2015)

Metabolic engineering of Escherichia coli for the biosynthesis of 2-pyrrolidone
por: Zhang, Jingwei, et al.
Publicado: (2015)

A truncated form of the Carbon catabolite repressor 1 increases cellulase production in Trichoderma reesei
por: Mello-de-Sousa, Thiago M, et al.
Publicado: (2014)

Genome-Wide Insight into Profound Effect of Carbon Catabolite Repressor (Cre1) on the Insect-Pathogenic Lifecycle of Beauveria bassiana
por: Mohamed, Rehab Abdelmonem, et al.
Publicado: (2021)

Multivariate modular metabolic engineering for enhanced l-methionine biosynthesis in Escherichia coli
por: Li, Zhongcai, et al.
Publicado: (2023)

Significantly improved solvent tolerance of Escherichia coli by global transcription machinery engineering
por: Zhang, Fa, et al.
Publicado: (2015)

Metabolic engineering of Escherichia coli for efficient biosynthesis of fluorescent phycobiliprotein
por: Chen, Huaxin, et al.
Publicado: (2019)

Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate
por: Ku, Jason T., et al.
Publicado: (2022)

The CRE1 carbon catabolite repressor of the fungus Trichoderma reesei: a master regulator of carbon assimilation
por: Portnoy, Thomas, et al.
Publicado: (2011)

RNA-seq data of Aspergillus tubingensis NBRC 31125 in carbon catabolite repressor related to xylanase production
por: Krisnawati, Ririn, et al.
Publicado: (2022)

Metabolomics for the design of new metabolic engineering strategies for improving aerobic succinic acid production in Escherichia coli
por: Valle, Antonio, et al.
Publicado: (2022)

Examining Escherichia coli glycolytic pathways, catabolite repression, and metabolite channeling using Δpfk mutants
por: Hollinshead, Whitney D., et al.
Publicado: (2016)

Metabolic engineering of Escherichia coli for de novo biosynthesis of vitamin B(12)
por: Fang, Huan, et al.
Publicado: (2018)

In silico profiling of cell growth and succinate production in Escherichia coli NZN111
por: Jian, Xingxing, et al.
Publicado: (2016)

Metabolic engineering of indole pyruvic acid biosynthesis in Escherichia coli with tdiD
por: Zhu, Yelin, et al.
Publicado: (2017)

Marker-Assisted Pyramiding of CRa and CRd Genes to Improve the Clubroot Resistance of Brassica rapa
por: Li, Xiaonan, et al.
Publicado: (2022)

Activity of Lac repressor anchored to the Escherichia coli inner membrane
por: Görke, Boris, et al.
Publicado: (2005)

Stochastic transcriptional pulses orchestrate flagellar biosynthesis in Escherichia coli
por: Kim, J. Mark, et al.
Publicado: (2020)

Enhancement of β-Alanine Biosynthesis in Escherichia coli Based on Multivariate Modular Metabolic Engineering
por: Xu, Jian, et al.
Publicado: (2021)

Disrupting Transcription and Folate Biosynthesis Leads to Synergistic Suppression of Escherichia coli Growth
por: Chen, Pei‐Hsin, et al.
Publicado: (2022)

Metabolic engineering of Escherichia coli carrying the hybrid acetone-biosynthesis pathway for efficient acetone biosynthesis from acetate
por: Yang, Hao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_6cpjnblafqepni0ggmm9vggqb8