­­LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation

The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain–interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1–interacting protein (HOIP), is a critical regulator of inflammation and immunity. This is highlighted by the fact th...

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Detalles Bibliográficos
Autores principales: Zinngrebe, Julia, Rieser, Eva, Taraborrelli, Lucia, Peltzer, Nieves, Hartwig, Torsten, Ren, Hongwei, Kovács, Ildikó, Endres, Cornelia, Draber, Peter, Darding, Maurice, von Karstedt, Silvia, Lemke, Johannes, Dome, Balazs, Bergmann, Michael, Ferguson, Brian J., Walczak, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110014/
https://www.ncbi.nlm.nih.gov/pubmed/27810922
http://dx.doi.org/10.1084/jem.20160041

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