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Dendritic cell sphingosine-1-phosphate lyase regulates thymic egress

T cell egress from the thymus is essential for adaptive immunity and involves chemotaxis along a sphingosine-1-phosphate (S1P) gradient. Pericytes at the corticomedullary junction produce the S1P egress signal, whereas thymic parenchymal S1P levels are kept low through S1P lyase (SPL)–mediated metab...

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Detalles Bibliográficos
Autores principales:	Zamora-Pineda, Jesus, Kumar, Ashok, Suh, Jung H., Zhang, Meng, Saba, Julie D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110016/ https://www.ncbi.nlm.nih.gov/pubmed/27810923 http://dx.doi.org/10.1084/jem.20160287

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