Scramblase TMEM16F terminates T cell receptor signaling to restrict T cell exhaustion

In chronic infection, T cells become hyporesponsive to antigenic stimulation to prevent immunopathology. Here, we show that TMEM16F is required to curb excessive T cell responses in chronic infection with virus. TMEM16F-deficient T cells are hyperactivated during the early phase of infection, exhibi...

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Detalles Bibliográficos
Autores principales: Hu, Yu, Kim, Ji Hyung, He, Kangmin, Wan, Qi, Kim, Jessica, Flach, Melanie, Kirchhausen, Tom, Vortkamp, Andrea, Winau, Florian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110022/
https://www.ncbi.nlm.nih.gov/pubmed/27810927
http://dx.doi.org/10.1084/jem.20160612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110022/
https://www.ncbi.nlm.nih.gov/pubmed/27810927
http://dx.doi.org/10.1084/jem.20160612

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