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Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective
Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110139/ https://www.ncbi.nlm.nih.gov/pubmed/27867482 http://dx.doi.org/10.4103/2045-9912.191360 |
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author | Shi, Shu-hai Qi, Zhi-feng Luo, Yu-min Ji, Xun-ming Liu, Ke Jian |
author_facet | Shi, Shu-hai Qi, Zhi-feng Luo, Yu-min Ji, Xun-ming Liu, Ke Jian |
author_sort | Shi, Shu-hai |
collection | PubMed |
description | Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies. |
format | Online Article Text |
id | pubmed-5110139 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51101392016-11-18 Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective Shi, Shu-hai Qi, Zhi-feng Luo, Yu-min Ji, Xun-ming Liu, Ke Jian Med Gas Res Review Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientific questions are still unclear, such as the therapeutic time window of NBO, the long-term effects and the benefits of NBO in large clinic trials. In this article, we review the current literatures on NBO treatment of acute ischemic stroke in preclinical and clinical studies and try to analyze and identify the key gaps or unknowns in our understanding about NBO. Based on these analyses, we provide suggestions for future studies. Medknow Publications & Media Pvt Ltd 2016-10-14 /pmc/articles/PMC5110139/ /pubmed/27867482 http://dx.doi.org/10.4103/2045-9912.191360 Text en Copyright: © 2016 Medical Gas Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Shi, Shu-hai Qi, Zhi-feng Luo, Yu-min Ji, Xun-ming Liu, Ke Jian Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title | Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title_full | Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title_fullStr | Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title_full_unstemmed | Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title_short | Normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
title_sort | normobaric oxygen treatment in acute ischemic stroke: a clinical perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110139/ https://www.ncbi.nlm.nih.gov/pubmed/27867482 http://dx.doi.org/10.4103/2045-9912.191360 |
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