SF2312 is a natural phosphonate inhibitor of Enolase

Despite being critical for energy generation in most forms of life, few if any microbial antibiotics specifically inhibit glycolysis. To develop a specific inhibitor of the glycolytic enzyme Enolase 2 for the treatment of cancers with deletion of Enolase 1, we modeled the synthetic tool compound inh...

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Detalles Bibliográficos
Autores principales: Leonard, Paul G., Satani, Nikunj, Maxwell, David, Lin, Yu-Hsi, Hammoudi, Naima, Peng, Zhenghong, Pisaneschi, Federica, Link, Todd M., Lee, Gilbert R., Sun, Duoli, Prasad, Basvoju A. Bhanu, Di Francesco, Maria Emilia, Czako, Barbara, Asara, John M., Wang, Y. Alan, Bornmann, William, DePinho, Ronald A., Muller, Florian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110371/
https://www.ncbi.nlm.nih.gov/pubmed/27723749
http://dx.doi.org/10.1038/nchembio.2195

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