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–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma

INTRODUCTION: Polymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far. AIM: To investigate the association b...

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Autores principales: Sobjanek, Michał, Zabłotna, Monika, Szczerkowska-Dobosz, Aneta, Ruckemann-Dziurdzińska, Katarzyna, Sokolowska-Wojdylo, Malgorzata, Nowicki, Roman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110628/
https://www.ncbi.nlm.nih.gov/pubmed/27881944
http://dx.doi.org/10.5114/ada.2016.62846
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author Sobjanek, Michał
Zabłotna, Monika
Szczerkowska-Dobosz, Aneta
Ruckemann-Dziurdzińska, Katarzyna
Sokolowska-Wojdylo, Malgorzata
Nowicki, Roman
author_facet Sobjanek, Michał
Zabłotna, Monika
Szczerkowska-Dobosz, Aneta
Ruckemann-Dziurdzińska, Katarzyna
Sokolowska-Wojdylo, Malgorzata
Nowicki, Roman
author_sort Sobjanek, Michał
collection PubMed
description INTRODUCTION: Polymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far. AIM: To investigate the association between monocyte chemoattractant protein 1 (MCP-1) (–2518 A/G) and RANTES (–403 G/A) polymorphism and risk and clinical course of BCC. MATERIAL AND METHODS: The study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers. The polymorphisms were analysed using the amplification refractory mutation system polymerase chain reaction method (ARMS-PCR) and single specific primer-polymerase chain reaction (SSP-PCR). Serum cytokine levels were measured with ELISA. RESULTS: The presence of the MCP-1 –2518 GG genotype was statistically more frequent in BCC patients and it increased the risk of BCC (OR = 2.63, p = 0.003). Genotype –330 GG was statistically more common in patients with less advanced tumours (OR = 2.8, p = 0.017). Monocyte chemoattractant protein 1 serum level was statistically higher with GG genotype. In the BCC group MCP-1 serum levels were decreased. Neither polymorphic variants of RANTES nor the chemokine serum concentration differed significantly between the study groups. CONCLUSIONS: These findings suggest that –2518 A/G MCP-1 polymorphism may be involved in BCC pathogenesis.
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spelling pubmed-51106282016-11-23 –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma Sobjanek, Michał Zabłotna, Monika Szczerkowska-Dobosz, Aneta Ruckemann-Dziurdzińska, Katarzyna Sokolowska-Wojdylo, Malgorzata Nowicki, Roman Postepy Dermatol Alergol Original Paper INTRODUCTION: Polymorphic variants of MCP-1 and RANTES genes and their protein serum levels have been implicated in the increased risk and severity of several malignancies. However, the subject has not been explored in basal cell carcinoma (BCC) patients so far. AIM: To investigate the association between monocyte chemoattractant protein 1 (MCP-1) (–2518 A/G) and RANTES (–403 G/A) polymorphism and risk and clinical course of BCC. MATERIAL AND METHODS: The study group consisted of 150 unrelated patients with BCC and 140 healthy, unrelated, age- and sex-matched volunteers. The polymorphisms were analysed using the amplification refractory mutation system polymerase chain reaction method (ARMS-PCR) and single specific primer-polymerase chain reaction (SSP-PCR). Serum cytokine levels were measured with ELISA. RESULTS: The presence of the MCP-1 –2518 GG genotype was statistically more frequent in BCC patients and it increased the risk of BCC (OR = 2.63, p = 0.003). Genotype –330 GG was statistically more common in patients with less advanced tumours (OR = 2.8, p = 0.017). Monocyte chemoattractant protein 1 serum level was statistically higher with GG genotype. In the BCC group MCP-1 serum levels were decreased. Neither polymorphic variants of RANTES nor the chemokine serum concentration differed significantly between the study groups. CONCLUSIONS: These findings suggest that –2518 A/G MCP-1 polymorphism may be involved in BCC pathogenesis. Termedia Publishing House 2016-10-21 2016-10 /pmc/articles/PMC5110628/ /pubmed/27881944 http://dx.doi.org/10.5114/ada.2016.62846 Text en Copyright: © 2016 Termedia Sp. z o.o. http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Original Paper
Sobjanek, Michał
Zabłotna, Monika
Szczerkowska-Dobosz, Aneta
Ruckemann-Dziurdzińska, Katarzyna
Sokolowska-Wojdylo, Malgorzata
Nowicki, Roman
–2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title_full –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title_fullStr –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title_full_unstemmed –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title_short –2518 A/G MCP-1 but not –403 G/A RANTES gene polymorphism is associated with enhanced risk of basal cell carcinoma
title_sort –2518 a/g mcp-1 but not –403 g/a rantes gene polymorphism is associated with enhanced risk of basal cell carcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110628/
https://www.ncbi.nlm.nih.gov/pubmed/27881944
http://dx.doi.org/10.5114/ada.2016.62846
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