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A Fatal Adverse Effect of Barbiturate Coma Therapy: Dyskalemia

The management guideline for traumatic brain injury (TBI) recommends high-dose barbiturate therapy to control increased intracranial pressure refractory to other therapeutic options. High-dose barbiturate therapy, however, may cause many severe side effects; the commonly recognized ones include hypo...

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Detalles Bibliográficos
Autores principales: Kwon, Hyun Mook, Baek, Jin Wook, Lee, Sang Pyung, Cho, Jae Ik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurotraumatology Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110908/
https://www.ncbi.nlm.nih.gov/pubmed/27857927
http://dx.doi.org/10.13004/kjnt.2016.12.2.156
Descripción
Sumario:The management guideline for traumatic brain injury (TBI) recommends high-dose barbiturate therapy to control increased intracranial pressure refractory to other therapeutic options. High-dose barbiturate therapy, however, may cause many severe side effects; the commonly recognized ones include hypotension, immunosuppression, hepatic dysfunction, renal dysfunction, and prolonged decrease of cortical activity. Meanwhile, dyskalemia remains relatively uncommon. In this study, we report the case of a hypokalemic patient with severe rebound hyperkalemia, which occurred as a result of barbiturate coma therapy administered for TBI treatment.