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Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review

Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment...

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Detalles Bibliográficos
Autores principales: Oh, Sun Kyu, Jeon, Sang Ryong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neurotraumatology Society 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110917/
https://www.ncbi.nlm.nih.gov/pubmed/27857906
http://dx.doi.org/10.13004/kjnt.2016.12.2.40
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author Oh, Sun Kyu
Jeon, Sang Ryong
author_facet Oh, Sun Kyu
Jeon, Sang Ryong
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description Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy. The result of the current research showed that direct intramedullary injection to the injured spinal cord site in subacute phase is most effective. Neurological examination, electrophysiologic studies, and magnetic resonance imaging are commonly used to assess the effectiveness of treatment. Diffusion tensor imaging visualizing white matter tract can be also alternative option to identify neuronal regeneration. Despite various challenging issues, stem cell therapy will open new perspectives for SCI treatment.
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spelling pubmed-51109172016-11-17 Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review Oh, Sun Kyu Jeon, Sang Ryong Korean J Neurotrauma Review Article Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy. The result of the current research showed that direct intramedullary injection to the injured spinal cord site in subacute phase is most effective. Neurological examination, electrophysiologic studies, and magnetic resonance imaging are commonly used to assess the effectiveness of treatment. Diffusion tensor imaging visualizing white matter tract can be also alternative option to identify neuronal regeneration. Despite various challenging issues, stem cell therapy will open new perspectives for SCI treatment. Korean Neurotraumatology Society 2016-10 2016-10-31 /pmc/articles/PMC5110917/ /pubmed/27857906 http://dx.doi.org/10.13004/kjnt.2016.12.2.40 Text en Copyright © 2016 Korean Neurotraumatology Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oh, Sun Kyu
Jeon, Sang Ryong
Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title_full Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title_fullStr Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title_full_unstemmed Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title_short Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
title_sort current concept of stem cell therapy for spinal cord injury: a review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110917/
https://www.ncbi.nlm.nih.gov/pubmed/27857906
http://dx.doi.org/10.13004/kjnt.2016.12.2.40
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