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Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review
Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Neurotraumatology Society
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110917/ https://www.ncbi.nlm.nih.gov/pubmed/27857906 http://dx.doi.org/10.13004/kjnt.2016.12.2.40 |
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author | Oh, Sun Kyu Jeon, Sang Ryong |
author_facet | Oh, Sun Kyu Jeon, Sang Ryong |
author_sort | Oh, Sun Kyu |
collection | PubMed |
description | Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy. The result of the current research showed that direct intramedullary injection to the injured spinal cord site in subacute phase is most effective. Neurological examination, electrophysiologic studies, and magnetic resonance imaging are commonly used to assess the effectiveness of treatment. Diffusion tensor imaging visualizing white matter tract can be also alternative option to identify neuronal regeneration. Despite various challenging issues, stem cell therapy will open new perspectives for SCI treatment. |
format | Online Article Text |
id | pubmed-5110917 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Korean Neurotraumatology Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-51109172016-11-17 Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review Oh, Sun Kyu Jeon, Sang Ryong Korean J Neurotrauma Review Article Spinal cord injury (SCI) is a catastrophic condition associated with significant neurological deficit, social, and financial burdens. Over the past decades, various treatments including medication, surgery, and rehabilitation therapy for SCI have been performed, but there were no definite treatment option to improve neurological function of patients with chronic SCI. Therefore, new treatment trials with stem cells have been studied to regenerate injured spinal cord. Among various types of stem cells, bone marrow derived mesenchymal stem cells is highly expected as candidates for the stem cell therapy. The result of the current research showed that direct intramedullary injection to the injured spinal cord site in subacute phase is most effective. Neurological examination, electrophysiologic studies, and magnetic resonance imaging are commonly used to assess the effectiveness of treatment. Diffusion tensor imaging visualizing white matter tract can be also alternative option to identify neuronal regeneration. Despite various challenging issues, stem cell therapy will open new perspectives for SCI treatment. Korean Neurotraumatology Society 2016-10 2016-10-31 /pmc/articles/PMC5110917/ /pubmed/27857906 http://dx.doi.org/10.13004/kjnt.2016.12.2.40 Text en Copyright © 2016 Korean Neurotraumatology Society http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Oh, Sun Kyu Jeon, Sang Ryong Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title | Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title_full | Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title_fullStr | Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title_full_unstemmed | Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title_short | Current Concept of Stem Cell Therapy for Spinal Cord Injury: A Review |
title_sort | current concept of stem cell therapy for spinal cord injury: a review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5110917/ https://www.ncbi.nlm.nih.gov/pubmed/27857906 http://dx.doi.org/10.13004/kjnt.2016.12.2.40 |
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